About: Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters

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About: Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters
Creator	Yu, M Baltina, L Konovalova, N Eropkin, Petrova, P
Source	Medline; PMC
abstract	Glycyrrhizic acid (GA) conjugates with methyl and ethyl esters of D-amino acids (D-Trp, D-Phe, D-Tyr, D-Val, D-Leu) have been synthesized by the activated esters method using mixtures of N-hydroxybenzotriazole or N-hydroxysuccinimide with N,N′-dicyclohexylcarbodiimide. GA conjugate with D-Trp ethyl ester exhibited antiviral activity against influenza viruses A/H3N2, A/H1N1/pdm09, A/H5N1, B (SI > 10–29), and HRSV (SI > 25). GA conjugate with D-Trp methyl ester inhibited influenza virus A/H1N1/pdm09 (SI > 30).
has issue date	2017-08-02(xsd:dateTime)
bibo:doi	10.1134/s1068162017040045
bibo:pmid	32214781
has license	no-cc
sha1sum (hex)	e043a23f7e10c7e80f7e63ba50bd12893e272be4
schema:url	https://doi.org/10.1134/s1068162017040045
resource representing a document's title	Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters
has PubMed Central identifier	PMC7088872
has PubMed identifier	32214781
schema:publication	Russ J Bioorgan Chem
resource representing a document's body	covid:e043a23f7e10c7e80f7e63ba50bd12893e272be4#body_text
is schema:about of	named entity 'ester' named entity 'Original' named entity 'HAVE' named entity 'CONJUGATE' named entity 'mixtures' named entity 'A/H1N1' named entity 'HRSV' named entity 'N-hydroxysuccinimide' named entity 'antiviral activity' named entity 'influenza viruses' named entity 'ethyl esters' named entity 'esters' named entity 'immunomodulators' named entity 'herpes simplex' named entity 'MeOH' named entity 'column chromatography' named entity 'spectrophotometer' named entity 'dye' named entity 'corticosteroid' named entity 'viruses' named entity 'ppm' named entity 'filtrate' named entity 'antiviral agent' named entity 'Glycyrrhizic acid' named entity 'hormones' named entity 'toxicity' named entity 'MDCK' named entity 'toxic compound' named entity 'Phe' named entity 'citric acid' named entity 'Cytopathic effect' named entity 'molar ratio' named entity 'D-amino acid' named entity 'titer' named entity 'COOH' named entity 'GMP' named entity 'H1N1' named entity 'gamma-interferon' named entity 'decimal logarithm' named entity 'silica gel' named entity 'mmol' named entity 'bioavailability' named entity 'Glycyrrhiza uralensis' named entity 'HRSV' named entity 'avian influenza virus' named entity 'licorice' named entity 'virus' named entity 'ester' named entity '3.5' named entity 'precipitate' named entity 'ppm' named entity 'DMSO' named entity 'triterpene' named entity 'H NMR' named entity 'natural compound' named entity 'antiviral' named entity 'D-amino acids' named entity 'antiviral activity' named entity 'influenza virus' named entity 'agglutination reaction' named entity 'gastrointestinal tract' named entity 'environmental factors' named entity 'NMR' named entity 'mmol' named entity 'liver' named entity 'virus' named entity 'thiazolyl' named entity 'ppm' named entity 'Trp' named entity 'ppm' named entity 'HRSV' named entity 'chronic hepatitis' named entity 'C=O' named entity 'carbon atom' named entity 'titer' named entity 'dicyclohexylurea' named entity 'mmol'

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