About: Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis
Creator	Zheng, Bo-Jian Chan, Jasper Fuk-Woo Yuen, Kwok-Yung Zhou, Jie Chan, Kwok-Hung Chu, Hin Li, Cun Cheng, Zhong-Shan Sun, Tianhao To, Kai-Wang Wong, Kwok, Vincent Poon, Man Wong, Yin Ho, Bosco Chan, Yu-Wai Choi-, Candy Kak-Yuen, Kenneth Lau, Yi
Source	Medline; PMC
abstract	Middle East respiratory syndrome coronavirus (MERS-CoV) infection caused severe pneumonia and multiorgan dysfunction and had a higher crude fatality rate (around 50% vs 10%) than SARS coronavirus (SARS-CoV) infection. To understand the pathogenesis, we studied viral replication, cytokine/chemokine response, and antigen presentation in MERS-CoV–infected human monocyte–derived macrophages (MDMs) versus SARS-CoV–infected MDMs. Only MERS-CoV can replicate in MDMs. Both viruses were unable to significantly stimulate the expression of antiviral cytokines (interferon α [IFN-α] and IFN-β) but induced comparable levels of tumor necrosis factor α and interleukin 6. Notably, MERS-CoV induced significantly higher expression levels of interleukin 12, IFN-γ, and chemokines (IP-10/CXCL-10, MCP-1/CCL-2, MIP-1α/CCL-3, RANTES/CCL-5, and interleukin 8) than SARS-CoV. The expression of major histocompatibility complex class I and costimulatory molecules were significantly higher in MERS-CoV–infected MDMs than in SARS-CoV–infected cells. MERS-CoV replication was validated by immunostaining of infected MDMs and ex vivo lung tissue. We conclusively showed that MERS-CoV can establish a productive infection in human macrophages. The aberrant induction of inflammatory cytokines/chemokines could be important in the disease pathogenesis.
has issue date	2014-05-01(xsd:dateTime)
bibo:doi	10.1093/infdis/jit504
bibo:pmid	24065148
has license	no-cc
sha1sum (hex)	e0344cab16912ac1eb3c55f8fc3edeb66e2d5b73
schema:url	https://doi.org/10.1093/infdis/jit504
resource representing a document's title	Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis
has PubMed Central identifier	PMC7107356
has PubMed identifier	24065148
schema:publication	J Infect Dis
resource representing a document's body	covid:e0344cab16912ac1eb3c55f8fc3edeb66e2d5b73#body_text
is schema:about of	named entity 'comparable' named entity 'antigen presentation' named entity 'antiviral' named entity 'Cytokines' named entity 'Macrophages' named entity 'Aberrant' named entity 'HUMAN' named entity 'ACTIVE' named entity 'DISEASE' named entity 'CYTOKINE' named entity 'INTERLEUKIN 6' named entity 'IMPORTANT' named entity 'DYSFUNCTION' named entity 'CYTOKINES' named entity 'RANTES' named entity 'EXPRESSION' named entity 'INTERLEUKIN 12' named entity 'INFECTION' named entity 'VALIDATED' named entity 'MOLECULES' named entity 'PATHOGENESIS' named entity 'LUNG TISSUE' named entity 'REPLICATE' named entity 'MACROPHAGES' named entity 'INDUCTION' named entity 'CYTOKINES' named entity 'RATE' named entity 'IFN' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'BUT' named entity 'EX VIVO' covid:arg/e0344cab16912ac1eb3c55f8fc3edeb66e2d5b73 named entity 'INDUCTION' named entity 'INFLAMMATORY' named entity 'ABERRANT' named entity 'SARS-COV' named entity 'VIRAL REPLICATION' named entity '50%' named entity 'ESTABLISH' named entity 'PATHOGENESIS' named entity 'MACROPHAGES' named entity 'COULD BE' named entity '10%' named entity 'LEVELS' named entity 'PRODUCTIVE' named entity 'DERIVED' named entity 'RESPONSE' named entity 'CELLS' named entity 'ANTIVIRAL' named entity 'SEVERE PNEUMONIA' named entity 'STIMULATE' named entity 'HUMAN MONOCYTE' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'INFECTED HUMAN' named entity 'MDMS' named entity 'SARS CORONAVIRUS' named entity 'INFECTED' named entity 'IMMUNOSTAINING' named entity 'HIGHER' named entity 'MCP-1' named entity 'CHEMOKINES' named entity 'UNDERSTAND' named entity 'INTERLEUKIN 8'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software