About: Nucleolin interacts with influenza A nucleoprotein and contributes to viral ribonucleoprotein complexes nuclear trafficking and efficient influenza viral replication

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About: Nucleolin interacts with influenza A nucleoprotein and contributes to viral ribonucleoprotein complexes nuclear trafficking and efficient influenza viral replication Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Nucleolin interacts with influenza A nucleoprotein and contributes to viral ribonucleoprotein complexes nuclear trafficking and efficient influenza viral replication
Creator	Lina, Bruno Diaz, Jean-Jacques Hacot, Sabine Rosa-Calatrava, Manuel Terrier, Olivier Lotteau, Vincent Moules, Vincent Carron, Coralie Cartet, Gaëlle De Chassey, Benoît Dubois, Julia Julien, Thomas Proust, Anaïs Ressnikoff, Denis Traversier, Aurélien Lyon, Claude Lyon, France
Source	Medline; PMC
abstract	Influenza viruses replicate their single-stranded RNA genomes in the nucleus of infected cells and these replicated genomes (vRNPs) are then exported from the nucleus to the cytoplasm and plasma membrane before budding. To achieve this export, influenza viruses hijack the host cell export machinery. However, the complete mechanisms underlying this hijacking remain not fully understood. We have previously shown that influenza viruses induce a marked alteration of the nucleus during the time-course of infection and notably in the nucleolar compartment. In this study, we discovered that a major nucleolar component, called nucleolin, is required for an efficient export of vRNPs and viral replication. We have notably shown that nucleolin interacts with the viral nucleoprotein (NP) that mainly constitutes vRNPs. Our results suggest that this interaction could allow vRNPs to “catch” the host cell export machinery, a necessary step for viral replication.
has issue date	2016-07-04(xsd:dateTime)
bibo:doi	10.1038/srep29006
bibo:pmid	27373907
has license	cc-by
sha1sum (hex)	e0111854ce52152339b685712b1a2843e3f1b839
schema:url	https://doi.org/10.1038/srep29006
resource representing a document's title	Nucleolin interacts with influenza A nucleoprotein and contributes to viral ribonucleoprotein complexes nuclear trafficking and efficient influenza viral replication
has PubMed Central identifier	PMC4931502
has PubMed identifier	27373907
schema:publication	Sci Rep
resource representing a document's body	covid:e0111854ce52152339b685712b1a2843e3f1b839#body_text
is schema:about of	named entity 'TRAFFICKING' named entity 'exploration' named entity 'Crm1' named entity 'VIRAL REPLICATION' named entity 'NUCLEOPROTEIN' named entity 'DEPENDENT' named entity 'RECENTLY' named entity 'CHROMATIN' named entity 'NUCLEAR EXPORT' named entity 'RESULTS' named entity 'HOST' named entity 'INTERACTION' named entity 'EXPLORATION' named entity 'NUCLEAR' named entity 'INVOLVEMENT' named entity 'DENSE' named entity 'VIRAL' named entity 'INFLUENZA' named entity 'MACHINERY' named entity 'PLACE' named entity 'INFLUENZA A' named entity 'OPEN' named entity 'TRAFFIC' named entity 'NUCLEAR' named entity 'NUCLEOLIN' named entity 'COMPLEXES' named entity 'EFFICIENT' named entity 'ALLOW' named entity 'CELLULAR' named entity 'CRM1' named entity 'REGULATING' named entity 'RIBONUCLEOPROTEIN' named entity 'COMPLEXES' named entity 'THESE' named entity 'OTHER OBSERVATIONS' covid:arg/e0111854ce52152339b685712b1a2843e3f1b839 named entity 'machinery' named entity 'nuclear export' named entity 'highlight' named entity 'substrates' named entity 'nuclear export' named entity 'Crm1' named entity 'nuclear export' named entity 'influenza' named entity 'Gene Ontology' named entity 'IAV' named entity 'histone tails' named entity 'nucleolin' named entity 'RNA' named entity 'chromatin' named entity 'B23' named entity 'protein complexes' named entity 'dye' named entity 'siRNA' named entity 'cytoplasmic' named entity 'viral protein' named entity 'Nucleolin' named entity 'endogenous' named entity 'NaCl' named entity 'nucleolin' named entity 'nucleolin' named entity 'lysate' named entity 'nucleus' named entity 'expression levels' named entity 'immunoprecipitation'

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