About: Acute complications and mortality in hospitalized patients with coronavirus disease 2019: a systematic review and meta-analysis

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About: Acute complications and mortality in hospitalized patients with coronavirus disease 2019: a systematic review and meta-analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Acute complications and mortality in hospitalized patients with coronavirus disease 2019: a systematic review and meta-analysis
Creator	Spoto, Silvia Abbate, Antonio Nisio, Marcello Porreca, Ettore Potere, Nicola Rutjes, Anne Valeriani, Emanuele Candeloro, Matteo Tana, Marco
Source	Medline; PMC
abstract	BACKGROUND: The incidence of acute complications and mortality associated with COVID-19 remains poorly characterized. The aims of this systematic review and meta-analysis were to summarize the evidence on clinically relevant outcomes in hospitalized patients with COVID-19. METHODS: MEDLINE, EMBASE, PubMed, and medRxiv were searched up to April 20, 2020, for studies including hospitalized symptomatic adult patients with laboratory-confirmed COVID-19. The primary outcomes were all-cause mortality and acute respiratory distress syndrome (ARDS). The secondary outcomes included acute cardiac or kidney injury, shock, coagulopathy, and venous thromboembolism. The main analysis was based on data from peer-reviewed studies. Summary estimates and the corresponding 95% prediction intervals (PIs) were obtained through meta-analyses. RESULTS: A total of 44 peer-reviewed studies with 14,866 COVID-19 patients were included. In general, risk of bias was high. All-cause mortality was 10% overall (95% PI, 2 to 39%; 1687/14203 patients; 43 studies), 34% in patients admitted to intensive care units (95% PI, 8 to 76%; 659/2368 patients; 10 studies), 83% in patients requiring invasive ventilation (95% PI, 1 to 100%; 180/220 patients; 6 studies), and 75% in patients who developed ARDS (95% PI, 35 to 94%; 339/455 patients; 11 studies). On average, ARDS occurred in 14% of patients (95% PI, 2 to 59%; 999/6322 patients; 23 studies), acute cardiac injury in 15% (95% PI, 5 to 38%; 452/2389 patients; 10 studies), venous thromboembolism in 15% (95% PI, 0 to 100%; patients; 3 studies), acute kidney injury in 6% (95% PI, 1 to 41%; 318/4682 patients; 15 studies), coagulopathy in 6% (95% PI, 1 to 39%; 223/3370 patients; 9 studies), and shock in 3% (95% PI, 0 to 61%; 203/4309 patients; 13 studies). CONCLUSIONS: Mortality was very high in critically ill patients based on very low-quality evidence due to striking heterogeneity and risk of bias. The incidence of clinically relevant outcomes was substantial, although reported by only one third of the studies suggesting considerable underreporting. TRIAL REGISTRATION: PROSPERO registration ID for this study is CRD42020177243 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=177243).
has issue date	2020-07-02(xsd:dateTime)
bibo:doi	10.1186/s13054-020-03022-1
bibo:pmid	32616077
has license	cc-by
sha1sum (hex)	dfed1df9e52cda3d3592df855518bebf6c5d0d1d
schema:url	https://doi.org/10.1186/s13054-020-03022-1
resource representing a document's title	Acute complications and mortality in hospitalized patients with coronavirus disease 2019: a systematic review and meta-analysis
has PubMed Central identifier	PMC7330272
has PubMed identifier	32616077
schema:publication	Crit Care
resource representing a document's body	covid:dfed1df9e52cda3d3592df855518bebf6c5d0d1d#body_text
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