About: Synthesis and structure-activity relationship studies of water-soluble β-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents

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About: Synthesis and structure-activity relationship studies of water-soluble β-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Synthesis and structure-activity relationship studies of water-soluble β-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents
Creator	Li, Man Jin, Hongwei Liang, Shuobin Xiao, Sulong Yu, Xiaojuan Zhang, Lihe Zhang, Yongmin Zhou, Demin
Source	Elsevier; Medline; PMC
abstract	Abstract Glycyrrhetinic acid (GA) is a major constituent of the herb Glycyrrhiza glabra, and many of its derivatives demonstrate a broad spectrum of antiviral activities. In the current study, 18 water-soluble β-cyclodextrin (CD)-GA conjugates, in which GA was covalently coupled to the primary face of β-CD using 1,2,3-triazole moiety along with varying lengths of linker, were synthesized via copper-catalyzed azide-alkyl cycloaddition reaction. Benefited from the attached β-CD moiety, all these conjugates showed lower hydrophobicity (AlogP) compared with their parent compound GA. With the exception of per-O-methylated β-CD-GA conjugate (35), all other conjugates showed no significant cytotoxicity to MDCK cells, and these conjugates were then screened against A/WSN/33 (H1N1) virus using the cytopathic effect assay. The preliminary results indicated that six conjugates showed promising antiviral activity, and the C-3 and C-30 of GA could tolerate some modifications. Our findings suggested that GA could be used as a lead compound for the development of potential anti-influenza virus agents.
has issue date	2019-03-15(xsd:dateTime)
bibo:doi	10.1016/j.ejmech.2019.01.074
bibo:pmid	30731401
has license	els-covid
sha1sum (hex)	dfd8a8d727848934c6196ac5764b13fe6649faa0
schema:url	https://doi.org/10.1016/j.ejmech.2019.01.074
resource representing a document's title	Synthesis and structure-activity relationship studies of water-soluble β-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents
has PubMed Central identifier	PMC7115653
has PubMed identifier	30731401
schema:publication	European Journal of Medicinal Chemistry
resource representing a document's body	covid:dfd8a8d727848934c6196ac5764b13fe6649faa0#body_text
is schema:about of	named entity 'INFLUENZA VIRUS' named entity 'MDCK CELLS' named entity 'ASSAY' named entity 'BROAD SPECTRUM' named entity 'CYTOPATHIC EFFECT' named entity 'WATER-SOLUBLE' named entity 'COPPER' named entity 'SYNTHESIZED' named entity 'AZIDE' named entity 'CYCLODEXTRIN' named entity 'POTENTIAL' named entity 'PRIMARY' named entity 'ANTIVIRAL ACTIVITY' named entity 'FINDINGS' named entity 'COMPARED' named entity 'INFLUENZA VIRUS' named entity 'VIRUS' named entity 'ALKYL' named entity 'USING' named entity 'USED' named entity 'ITS' named entity 'FACE' named entity 'IS A' named entity 'CONSTITUENT' named entity 'VARYING' named entity 'LINKER' named entity 'POTENTIAL' named entity 'CYCLODEXTRIN' named entity 'EXCEPTION' named entity 'CYTOTOXICITY' named entity 'ATTACHED' named entity 'TRIAZOLE' named entity 'LENGTHS' named entity 'DEVELOPMENT' named entity 'GLYCYRRHETINIC ACID' named entity 'PRELIMINARY RESULTS' named entity 'HYDROPHOBICITY' named entity 'GLYCYRRHIZA GLABRA' covid:arg/dfd8a8d727848934c6196ac5764b13fe6649faa0 named entity 'LOWER' named entity 'OUR' named entity 'SIGNIFICANT' named entity 'THEIR' named entity 'CONJUGATE' named entity 'SYNTHESIS' named entity 'CONJUGATES' named entity 'COULD BE' named entity 'STUDY' named entity 'THESE' named entity 'CONJUGATES' named entity 'INDICATED' named entity 'HERB' named entity 'A MAJOR' named entity 'PARENT' named entity 'COMPOUND' named entity 'ANTIVIRAL' named entity 'METHYLATED' named entity 'COUPLED' named entity 'CURRENT' named entity 'LEAD COMPOUND' named entity 'STUDIES' named entity 'ACTIVITIES' named entity 'STRUCTURE-ACTIVITY RELATIONSHIP' named entity 'GLYCYRRHETINIC ACID' named entity 'WATER-SOLUBLE' named entity 'CYCLOADDITION REACTION' named entity 'MOIETY' named entity 'broad spectrum' named entity 'virus' named entity 'H1N1' named entity 'azide' named entity 'moiety' named entity 'cytotoxicity' named entity 'virus'

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