About: Ribavirin inhibits Zika virus (ZIKV) replication in vitro and suppresses viremia in ZIKV-infected STAT1-deficient mice

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About: Ribavirin inhibits Zika virus (ZIKV) replication in vitro and suppresses viremia in ZIKV-infected STAT1-deficient mice Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ribavirin inhibits Zika virus (ZIKV) replication in vitro and suppresses viremia in ZIKV-infected STAT1-deficient mice
Creator	Kobayashi, Takashi Takasaki, Tomohiko Eshita, Yuki Fukuda, Chiaki Gendo, Yoshiko Hidano, Shinya Kamiyama, Naganori Matsubara, Etsuro Miura, Yumako Noguchi, Kaori Ozaki, Takashi Sachi, Nozomi Soma, Ryusuke Sonoda, Akira Tajima, Shigeru Umekita, Hiroshi Watanabe, Kei Runtuwene, Lucky
Source	Elsevier; Medline; PMC
abstract	Abstract Zika fever, a mosquito-borne infectious disease caused by Zika virus (ZIKV), is an epidemic disease for which no effective therapy has been established. The recent outbreaks of ZIKV in Brazil and French Polynesia have been linked to a considerable increase in the incidence of fetal microcephaly and other diseases such as Guillain-Barre syndrome. Because there is currently no specific therapy or vaccine, the early exploitation of a method to prevent expansion of ZIKV is a high priority. To validate commonly used antiviral drugs, we evaluated the effect of ribavirin, a drug used to treat hepatitis C with interferon-β (IFN-β), on ZIKV replication. In mammalian cells, we observed an inhibitory effect of ribavirin on ZIKV replication and ZIKV-induced cell death without cytotoxic effect. Furthermore, we found that STAT1-deficient mice, which lack type I IFN signaling, were highly sensitive to ZIKV infection and exhibited lethal outcome. Ribavirin abrogated viremia in ZIKV-infected STAT-1-deficient mice. These data suggest that the inhibition of viral RNA-dependent RNA polymerases may be effective for treatment of ZIKV infection. Our data provide a new insight into the mechanisms for inhibition of ZIKV replication and prevention of Zika fever.
has issue date	2017-10-31(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2017.08.007
bibo:pmid	28818572
has license	els-covid
sha1sum (hex)	dfd5bb84bc6b88bf01e7bd2a6bf5f8a4ad8e2033
schema:url	https://doi.org/10.1016/j.antiviral.2017.08.007
resource representing a document's title	Ribavirin inhibits Zika virus (ZIKV) replication in vitro and suppresses viremia in ZIKV-infected STAT1-deficient mice
has PubMed Central identifier	PMC7113888
has PubMed identifier	28818572
schema:publication	Antiviral Research
resource representing a document's body	covid:dfd5bb84bc6b88bf01e7bd2a6bf5f8a4ad8e2033#body_text
is schema:about of	named entity 'MICE' named entity 'INFECTED' named entity 'vaccine' named entity 'cell death' named entity 'mosquito-borne infectious disease' named entity 'effective' named entity 'viremia' named entity 'IN VITRO' named entity 'SUGGEST' named entity 'RIBAVIRIN' named entity 'GUILLAIN-BARRE SYNDROME' named entity 'ANTIVIRAL DRUGS' named entity 'CELL DEATH' named entity 'INHIBITION' named entity 'VIREMIA' named entity 'INCREASE' named entity 'FETAL MICROCEPHALY' named entity 'PREVENTION OF' named entity 'SPECIFIC' named entity 'HIGHLY SENSITIVE' named entity 'VACCINE' named entity 'INTERFERON-B' named entity 'BRAZIL' named entity 'CURRENTLY' named entity 'INDUCED' named entity 'FRENCH POLYNESIA' named entity 'MICE' named entity 'METHOD' named entity 'EFFECTIVE' named entity 'EFFECT' named entity 'IFN' named entity 'DEPENDENT' named entity 'EVALUATED' named entity 'USED' named entity 'EXPANSION' named entity 'CELLS' named entity 'OUR' named entity 'MAMMALIAN' named entity 'LACK' named entity 'MOSQUITO-BORNE INFECTIOUS DISEASE' named entity 'MAY BE' named entity 'STAT-1' named entity 'MECHANISMS' named entity 'REPLICATION' named entity 'OBSERVED' named entity 'INCIDENCE' named entity 'IS A' named entity 'ZIKA VIRUS' named entity 'RIBAVIRIN' named entity 'SUPPRESSES' named entity 'VIREMIA' named entity 'STAT1' named entity 'LETHAL' named entity 'OUTCOME' named entity 'TYPE I' named entity 'POLYMERASES' named entity 'THESE' named entity 'DRUG USED' named entity 'EARLY' named entity 'TO PREVENT' named entity 'INHIBITORY EFFECT' named entity 'HIGH PRIORITY' named entity 'PROVIDE' named entity 'ZIKA FEVER'

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