About: Possible involvement of infection with human coronavirus 229E, but not NL63, in Kawasaki disease

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About: Possible involvement of infection with human coronavirus 229E, but not NL63, in Kawasaki disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Possible involvement of infection with human coronavirus 229E, but not NL63, in Kawasaki disease
Creator	Matsuyama, Shutoku Shirato, Kazuya Taguchi, Fumihiro Kawase, Miyuki Nakagaki, Keiko Imada, Yoshio
source	Medline; PMC
abstract	Although human coronavirus (HCoV)‐NL63 was once considered a possible causative agent of Kawasaki disease based on RT‐PCR analyses, subsequent studies could not confirm the result. In this study, this possibility was explored using serological tests. To evaluate the role of HCoV infection in patients with Kawasaki disease, immunofluorescence assays and virus neutralizing tests were performed. Paired serum samples were obtained from patients with Kawasaki disease who had not been treated with γ‐globulin. HCoV‐NL63 and two antigenically different isolates of HCoV‐229E (ATCC‐VR740 and a new isolate, Sendai‐H) were examined as controls. Immunofluorescence assays detected no difference in HCoV‐NL63 antibody positivity between the patients with Kawasaki disease and controls, whereas the rate of HCoV‐229E antibody positivity was higher in the patients with Kawasaki disease than that in controls. The neutralizing tests revealed no difference in seropositivity between the acute and recovery phases of patients with Kawasaki disease for the two HCoV‐229Es. However, the Kawasaki disease specimens obtained from patients in recovery phase displayed significantly higher positivity for Sendai‐H, but not for ATCC‐VR740, as compared to the controls. The serological test supported no involvement of HCoV‐NL63 but suggested the possible involvement of HCoV‐229E in the development of Kawasaki disease. J. Med. Virol. 86:2146–2153, 2014. © 2014 Wiley Periodicals, Inc.
has issue date	2014-04-24(xsd:dateTime)
bibo:doi	10.1002/jmv.23950
bibo:pmid	24760654
has license	no-cc
sha1sum (hex)	dfcae249c352814e5fd2d145109d0911afa0b5a0
schema:url	https://doi.org/10.1002/jmv.23950
resource representing a document's title	Possible involvement of infection with human coronavirus 229E, but not NL63, in Kawasaki disease
has PubMed Central identifier	PMC7166330
has PubMed identifier	24760654
schema:publication	J Med Virol
resource representing a document's body	covid:dfcae249c352814e5fd2d145109d0911afa0b5a0#body_text
is schema:about of	named entity 'Human Coronavirus 229E' named entity 'Coronavirus 229E' named entity 'serological' named entity 'incubation' named entity 'RNA virus' named entity 'heat shock proteins' named entity 'viral infection' named entity 'virus infection' named entity 'Memphis, TN' named entity 'serological tests' named entity 'Japan' named entity 'HCoV-NL63' named entity 'DMEM' named entity 'serum' named entity 'Yanagawa' named entity 'HCoV-229E' named entity 'serological tests' named entity 'Fukaya' named entity 'HeLa' named entity 'antigens' named entity 'inclusion bodies' named entity 'HCoV-229E' named entity 'virus' named entity 'infection' named entity 'common cold' named entity 'HCoV-229E' named entity 'Kawasaki disease' named entity 'Belay' named entity 'Kawasaki disease' named entity 'Culture Collection' named entity 'Sendai' named entity 'globulin' named entity 'feline coronavirus' named entity 'virus' named entity 'phosphate-buffered saline' named entity 'Carl Zeiss' named entity 'Kawasaki disease' named entity 'pathogens' named entity 'HCoV-NL63' named entity 'Fisher's exact test' named entity 'pseudotyped' named entity 'infection' named entity 'Immunofluorescence assays' named entity 'causative agent' named entity 'Kawasaki disease' named entity 'febrile' named entity 'HCoV-NL63' named entity 'HCoV-NL63' named entity 'Kawasaki disease' named entity 'Sendai' named entity 'viruses' named entity 'virus' named entity 'serum' named entity 'Virus infection' named entity 'systemic vasculitis' named entity 'inclusion bodies' named entity 'Staphylococcus' named entity 'immunofluorescence assays' named entity 'Kawasaki disease' named entity 'Kawasaki disease' named entity 'Kawasaki disease' named entity 'epidemiological surveillance' named entity 'VSV' named entity 'Kawasaki disease' named entity 'HCoV-229E' named entity 'Sendai' named entity 'Japan' named entity 'cohort studies' named entity 'HCoV-229E' named entity 'viruses' named entity 'viral infection' named entity 'polyclonal' named entity 'Kawasaki disease' named entity 'causative agent' named entity 'antigens' named entity 'HCoV-229E'

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