About: Gene-expression reversal of lncRNAs and associated mRNAs expression in active vs latent HIV infection

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About: Gene-expression reversal of lncRNAs and associated mRNAs expression in active vs latent HIV infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Gene-expression reversal of lncRNAs and associated mRNAs expression in active vs latent HIV infection
Creator	Nair, Madhavan Pilakka-Kanthikeel, Sudheesh Sagar, Vidya
Source	Medline; PMC
abstract	Interplay between lncRNAs and mRNAs is rapidly emerging as a key epigenetic mechanism in controlling various cell functions. HIV can actively infect and/or can persist latently for years by manipulating host epigenetics; however, its molecular essence remains undiscovered in entirety. Here for the first time, we delineate the influence of HIV on global lncRNAs expression in monocytic cells lines. Our analysis revealed the expression modulation of nearly 1060 such lncRNAs which are associated with differentially expressed mRNAs in active and latent infection. This suggests a greater role of lncRNAs in regulating transcriptional and post-transcriptional gene expression during HIV infection. The differentially expressed mRNAs were involved in several different biological pathways where immunological networks were most enriched. Importantly, we discovered that HIV induces expression reversal of more than 150 lncRNAs between its active and latent infection. Also, hundreds of unique lncRNAs were identified in both infection conditions. The pathology specific “gene-expression reversal” and “on-and-off” switching of lncRNAs and associated mRNAs may lead to establish the relationship between active and HIV infection.
has issue date	2016-10-19(xsd:dateTime)
bibo:doi	10.1038/srep34862
bibo:pmid	27756902
has license	cc-by
sha1sum (hex)	dfc76bec0889529fc8cfd5075db5b638ee8cefbc
schema:url	https://doi.org/10.1038/srep34862
resource representing a document's title	Gene-expression reversal of lncRNAs and associated mRNAs expression in active vs latent HIV infection
has PubMed Central identifier	PMC5069461
has PubMed identifier	27756902
schema:publication	Sci Rep
resource representing a document's body	covid:dfc76bec0889529fc8cfd5075db5b638ee8cefbc#body_text
is schema:about of	named entity 'discovered' named entity 'The' named entity 'HIV' named entity 'expression' covid:arg/dfc76bec0889529fc8cfd5075db5b638ee8cefbc named entity 'OUR' named entity 'POST' named entity 'PATHOLOGY' named entity 'REVERSAL' named entity 'MODULATION' named entity 'IDENTIFIED' named entity 'CONDITIONS' named entity 'MRNAS' named entity 'HERE' named entity '150' named entity 'EXPRESSED' named entity 'NETWORKS' named entity 'INVOLVED' named entity 'NEARLY' named entity 'SWITCHING' named entity 'ENRICHED' named entity 'TRANSCRIPTIONAL' named entity 'MORE THAN' named entity 'HIV' named entity 'DELINEATE' named entity 'REVEALED' named entity 'LEAD' named entity 'BIOLOGICAL PATHWAYS' named entity 'RELATIONSHIP' named entity 'TIME' named entity 'LATENT' named entity 'ITS' named entity 'GENE EXPRESSION' named entity 'INFECTION' named entity 'REGULATING' named entity 'SPECIFIC' named entity 'ACTIVE' named entity 'UNIQUE' named entity 'IMMUNOLOGICAL' named entity 'EXPRESSION' named entity 'HIV INFECTION' named entity 'ACTIVE' named entity 'GENE-EXPRESSION' named entity 'CELLS LINES' named entity 'ROLE' named entity 'INFLUENCE' named entity 'OPEN' named entity 'REVERSAL' named entity 'DIFFERENT' named entity 'GLOBAL' named entity 'GREATER' named entity 'LATENT INFECTION' named entity 'MONOCYTIC' named entity 'MRNAS' named entity 'ASSOCIATED' named entity 'HUNDREDS' named entity 'WHERE' named entity 'HIV INFECTION' named entity 'ASSOCIATED WITH' named entity 'EXPRESSION' named entity 'ASSOCIATED' named entity 'ESTABLISH' named entity 'ANALYSIS' named entity 'global' named entity 'HIV' named entity 'latent infection' named entity 'enriched' named entity 'expression' named entity 'reversal' named entity 'lncRNAs' named entity 'regulating' named entity 'pathology' named entity 'HIV' named entity 'lncRNAs' named entity 'HIV' named entity 'mRNAs' named entity 'transcriptional' named entity 'mRNAs' named entity 'HIV'

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