About: Induction of Th1 type response by DNA vaccinations with N, M, and E genes against SARS-CoV in mice

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About: Induction of Th1 type response by DNA vaccinations with N, M, and E genes against SARS-CoV in mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Induction of Th1 type response by DNA vaccinations with N, M, and E genes against SARS-CoV in mice
Creator	Wang, Bin Yu, Yang Chen, Ze Jin, Huali Kang, Youmin Ma, Yijie Tu, Yixian Xiao, Chong Xie, Qifa Zhu, Kaichun
Source	Elsevier; Medline; PMC
abstract	Abstract Vaccination against the SARS-CoV infection is an attractive means to control the spread of viruses in public. In this study, we employed a DNA vaccine technology with the levamisole, our newly discovered chemical adjuvant, to generate Th1 type of response. To avoid the enhancement antibody issue, genes encoding the nucleocapsid, membrane, and envelope protein of SARS-CoV were cloned and their expressions in mammalian cells were determined. After the intramuscular introduction into animals, we observed that the constructs of the E, M, and N genes could induce high levels of specific antibodies, T cell proliferations, IFN-γ, DTH responses, and in vivo cytotoxic T cells activities specifically against SARS-CoV antigens. The highest immune responses were generated by the construct encoding the nucleocapsid protein. The results suggest that the N, M, and E genes could be used as the targets to prevent SARS-CoV infection in the DNA vaccine development.
has issue date	2005-03-25(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2005.01.048
bibo:pmid	15707974
has license	els-covid
sha1sum (hex)	dfa36995fa73b084f16263b967c78c156cc4e0bb
schema:url	https://doi.org/10.1016/j.bbrc.2005.01.048
resource representing a document's title	Induction of Th1 type response by DNA vaccinations with N, M, and E genes against SARS-CoV in mice
has PubMed Central identifier	PMC7092846
has PubMed identifier	15707974
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:dfa36995fa73b084f16263b967c78c156cc4e0bb#body_text
is schema:about of	named entity 'EMPLOYED' named entity 'RESPONSE' named entity 'DNA VACCINE' named entity 'LEVAMISOLE' named entity 'MEMBRANE' named entity 'PROTEIN ' named entity 'INTRAMUSCULAR' named entity 'HIGH' named entity 'VACCINE DEVELOPMENT' named entity 'OUR' named entity 'MAMMALIAN' named entity 'EXPRESSIONS' named entity 'SPECIFIC' named entity 'IMMUNE RESPONSES' named entity 'NUCLEOCAPSID PROTEIN' named entity 'T CELL' named entity 'TARGETS' named entity 'NEWLY DISCOVERED' named entity 'GENERATE' named entity 'GENES' named entity 'ENHANCEMENT' named entity 'USED' named entity 'Th1' named entity 'attractive' named entity 'avoid' named entity 'ANTIBODY' named entity 'LEVELS' named entity 'TECHNOLOGY' named entity 'RESULTS' named entity 'SUGGEST' named entity 'CHEMICAL' named entity 'INTRODUCTION' named entity 'ATTRACTIVE' named entity 'ENCODING' named entity 'VACCINATION' named entity 'STUDY' named entity 'PROLIFERATIONS' named entity 'OBSERVED' named entity 'ANIMALS' named entity 'GENERATED' named entity 'TYPE' named entity 'IN VIVO' named entity 'ISSUE' named entity 'ANTIBODIES' named entity 'DETERMINED' named entity 'DTH' named entity 'IFN' named entity 'CLONED' named entity 'CYTOTOXIC T CELLS' named entity 'A DNA' named entity 'VIRUSES' named entity 'TO CONTROL' named entity 'ANTIGENS' named entity 'SPREAD' named entity 'COULD BE' named entity 'TO PREVENT' named entity 'INDUCE' named entity 'TO AVOID' named entity 'SARS-COV' named entity 'HIGHEST' named entity 'RESPONSES' named entity 'TH1' named entity 'CELLS' named entity 'PUBLIC' named entity 'CONSTRUCT' named entity 'ADJUVANT' named entity 'ENVELOPE PROTEIN' named entity 'MEANS' named entity 'ACTIVITIES' named entity 'SARS-COV INFECTION' named entity 'NUCLEOCAPSID' named entity 'THEIR'

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