About: Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits

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About: Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits
Creator	Jiang, Yan Bé Rubé, Nathalie Bé, Nathalie Dumeaux, Vanessa Ellegood, Jacob Langlois, Luana Lerch, Jason Qiu, Lily Shafiq, Sarfraz Tamming, Renee
Source	Elsevier; Medline; PMC
abstract	ATRX gene mutations have been identified in syndromic and non-syndromic intellectual disabilities in humans. ATRX is known to maintain genomic stability in neuroprogenitor cells, but its function in differentiated neurons and memory processes remains largely unresolved. Here, we show that the deletion of neuronal Atrx in mice leads to distinct hippocampal structural defects, fewer presynaptic vesicles, and an enlarged postsynaptic area at CA1 apical dendrite-axon junctions. We identify male-specific impairments in long-term contextual memory and in synaptic gene expression, linked to altered miR-137 levels. We show that ATRX directly binds to the miR-137 locus and that the enrichment of the suppressive histone mark H3K27me3 is significantly reduced upon the loss of ATRX. We conclude that the ablation of ATRX in excitatory forebrain neurons leads to sexually dimorphic effects on miR-137 expression and on spatial memory, identifying a potential therapeutic target for neurological defects caused by ATRX dysfunction.
has issue date	2020-06-30(xsd:dateTime)
bibo:doi	10.1016/j.celrep.2020.107838
bibo:pmid	32610139
has license	no-cc
sha1sum (hex)	df7653219a4ab4a9deaba4a4fd6db39a673454cf
schema:url	https://doi.org/10.1016/j.celrep.2020.107838
resource representing a document's title	Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits
has PubMed Central identifier	PMC7326465
has PubMed identifier	32610139
schema:publication	Cell Rep
resource representing a document's body	covid:df7653219a4ab4a9deaba4a4fd6db39a673454cf#body_text
is schema:about of	named entity 'enlarged' named entity 'Deletion' named entity 'Neurons' named entity 'Learning' named entity 'Deletion' named entity 'ATRX GENE' named entity 'MEMORY' named entity 'LEADS' named entity 'VESICLES' named entity 'ITS' named entity 'H3K27ME3' named entity 'IDENTIFY' named entity 'function' named entity 'maintain' named entity 'postsynaptic' named entity 'syndromic' named entity 'differentiated' named entity 'hippocampal' named entity 'area' named entity 'apical' named entity 'ATRX' named entity 'levels' named entity 'expression' named entity 'transcripts' named entity 'presynaptic' named entity 'Neurons' named entity 'Spatial' named entity 'Atrx' named entity 'Atrx' named entity 'ATRX' named entity 'ATRX' named entity 'neurons' named entity 'gene mutations' named entity 'apical dendrite' named entity 'genomic stability' named entity 'miR' named entity 'Neurons' named entity 'Atrx' named entity 'Neurons' named entity 'Spatial Learning and Memory' named entity 'mice' named entity 'hippocampus' named entity 'pyramidal neurons' named entity 'mice' named entity 'binding sites' named entity 'CCCTC-binding factor' named entity 'hippocampus' named entity 'reverse transcribed' named entity 'ATRX' named entity 'PBS' named entity 'ATRX' named entity 'forebrain' named entity 'mice' named entity 'nickel' named entity 'ATRX' named entity 'DNA damage' named entity 'gene' named entity 'Atrx' named entity 'morphological' named entity 'qRT-PCR' named entity 'neurons' named entity 'central nervous' named entity 'Atrx' named entity 'wild-type' named entity 'ANOVA' named entity 'BioRad' named entity '60 minutes' named entity 'Atrx' named entity 'locomotion' named entity 'cKO' named entity 'cerebellar atrophy' named entity 'primers'

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