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About:
Proceedings from the 2(nd) Next Gen Therapies for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome symposium held on October 3-4, 2019
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An Entity of Type :
schema:ScholarlyArticle
, within Data Space :
covidontheweb.inria.fr
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document(s)
Type:
Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
has title
Proceedings from the 2(nd) Next Gen Therapies for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome symposium held on October 3-4, 2019
Creator
Schulert, Grant
Debenedetti, Fabrizio
Canna, Scott
Gadina, Massimo
Grom, Alexei
Boutelle, Jonathan
Brunner, Hermine
De Jesus, Adriana
Goldbach-Mansky, Raphaela
Levine, Stewart
Pickering, Alex
Sinha, Rashmi
Source
PMC
abstract
For reasons poorly understood, and despite the availability of biological medications blocking IL-1 and IL-6 that have markedly improved overall disease control, children with Systemic Juvenile Idiopathic Arthritis (SJIA) are now increasingly diagnosed with life-threatening chronic complications, including hepatitis and lung disease (SJIA-LD). On October 3–4, 2019, a two-day meeting, NextGen Therapies for Systemic Juvenile Idiopathic Arthritis (SJIA) & macrophage activation syndrome (MAS) organized by the Systemic JIA Foundation (www.systemicjia.org/) in Washington, DC brought together scientists, clinicians, parents and FDA representatives with the objectives (1) to integrate clinical and research findings in MAS and SJIA-LD, and (2) to develop a shared understanding of this seemingly new pulmonary complication of SJIA. The current manuscript summarizes discussions and conclusions of the meeting.
has issue date
2020-07-15
(
xsd:dateTime
)
bibo:doi
10.1186/s12969-020-00444-7
has license
cc-by
sha1sum (hex)
df4f95264864730bb3246d75eb6445c15572d4b6
schema:url
https://doi.org/10.1186/s12969-020-00444-7
resource representing a document's title
Proceedings from the 2(nd) Next Gen Therapies for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome symposium held on October 3-4, 2019
has PubMed Central identifier
PMC7360380
schema:publication
Pediatr Rheumatol Online J
resource representing a document's body
covid:df4f95264864730bb3246d75eb6445c15572d4b6#body_text
is
schema:about
of
named entity 'Juvenile Idiopathic Arthritis'
named entity 'Systemic'
named entity 'IL-1'
named entity 'CONCLUSIONS'
named entity 'DISCUSSIONS'
named entity 'DISEASE CONTROL'
named entity 'TO INTEGRATE'
named entity 'LIFE'
named entity 'Foundation'
named entity 'develop'
named entity 'complication'
named entity 'summarizes'
named entity 'disease'
named entity '2019'
named entity 'manuscript'
named entity 'SJIA'
named entity 'Systemic Juvenile Idiopathic Arthritis'
named entity 'MAS'
named entity 'Systemic Juvenile Idiopathic Arthritis'
named entity 'Systemic Juvenile Idiopathic Arthritis'
named entity 'histopathologic features'
named entity 'alveolar'
named entity 'Europe'
named entity 'methotrexate'
named entity 'innate immune'
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named entity 'cytokines'
named entity 'NLRC4'
named entity 'speech therapy'
named entity 'lipids'
named entity 'gene expression profile'
named entity 'Systemic Juvenile Idiopathic Arthritis'
named entity 'Novartis'
named entity 'lung lavage'
named entity 'steroids'
named entity 'Systemic Juvenile Idiopathic Arthritis'
named entity 'rash'
named entity 'MAS'
named entity 'pneumonia'
named entity 'combination therapy'
named entity 'immune responses'
named entity 'PRO'
named entity 'lung inflammation'
named entity 'liver abnormalities'
named entity 'CD4'
named entity 'tachypnea'
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named entity 'cytokine'
named entity 'productive cough'
named entity 'tocilizumab'
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named entity 'viral infection'
named entity 'HRCT'
named entity 'fatigue'
named entity 'LDH'
named entity 'immunosuppression'
named entity 'interferon'
named entity 'Systemic Juvenile Idiopathic Arthritis'
named entity 'Systemic Juvenile Idiopathic Arthritis'
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named entity 'canakinumab'
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named entity 'homeostasis'
named entity 'Systemic Juvenile Idiopathic Arthritis'
named entity 'azathioprine'
named entity 'MAS'
named entity 'therapeutic strategies'
named entity 'Kupffer cells'
named entity 'MAS'
named entity 'SJIA'
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