About: N-Propargylated isatin-Mannich mono- and bis-adducts: Synthesis and preliminary analysis of in vitro activity against Tritrichomonas foetus

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About: N-Propargylated isatin-Mannich mono- and bis-adducts: Synthesis and preliminary analysis of in vitro activity against Tritrichomonas foetus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	N-Propargylated isatin-Mannich mono- and bis-adducts: Synthesis and preliminary analysis of in vitro activity against Tritrichomonas foetus
Creator	Kumar, Vipan Arora, Reena Bhargava, Gaurav Chang, Kai-Hsiang Kumar, Kewal Sen, Somdutta Land, Kirkwood
Source	Elsevier; Medline; PMC
abstract	Abstract Cu(I)Cl promoted synthesis of N-propargylated-isatin Mannich mono- and bis-adducts with an extension towards the synthesis of N-propargylated-isatin-7-chloroquinoline conjugates was described. The synthesized scaffolds were evaluated for their in vitro activity against the veterinary protozoal pathogen Tritrichomonas foetus and cytotoxicity against human prostate (PC-3) cancer cell line. The preliminary evaluation data revealed the enhancement in the activity profiles with the introduction of 7-chloroquinoline ring with the most active conjugates 7a, 7c and 7d exhibiting an IC50 of 22.2, 11.3 and 24.5 μM respectively against T. foetus and minimal toxicity against human prostate (PC-3) cell lines.
has issue date	2014-03-03(xsd:dateTime)
bibo:doi	10.1016/j.ejmech.2014.01.015
bibo:pmid	24561663
has license	els-covid
sha1sum (hex)	df47877316cb0e933f51e875c1c12d881fd8a42f
schema:url	https://doi.org/10.1016/j.ejmech.2014.01.015
resource representing a document's title	N-Propargylated isatin-Mannich mono- and bis-adducts: Synthesis and preliminary analysis of in vitro activity against Tritrichomonas foetus
has PubMed Central identifier	PMC7115568
has PubMed identifier	24561663
schema:publication	European Journal of Medicinal Chemistry
resource representing a document's body	covid:df47877316cb0e933f51e875c1c12d881fd8a42f#body_text
is schema:about of	named entity 'synthesized' named entity 'ring' named entity 'Tritrichomonas' named entity 'PROTOZOAL' named entity 'CANCER CELL LINE' covid:arg/df47877316cb0e933f51e875c1c12d881fd8a42f named entity 'EXHIBITING' named entity 'THEIR' named entity 'DESCRIBED' named entity 'PATHOGEN' named entity 'BIS' named entity 'CONJUGATES' named entity 'SCAFFOLDS' named entity 'TOXICITY' named entity 'RING' named entity 'MINIMAL' named entity 'CELL LINES' named entity 'DATA' named entity 'EVALUATED' named entity '5 MM' named entity 'ACTIVE' named entity 'ISATIN' named entity 'EXTENSION' named entity 'PROSTATE' named entity '28I' named entity 'VETERINARY' named entity 'FOETUS' named entity 'HUMAN' named entity 'CYTOTOXICITY' named entity 'TRITRICHOMONAS FOETUS' named entity 'SYNTHESIS' named entity 'ENHANCEMENT' named entity 'IN VITRO ACTIVITY' named entity 'REVEALED' named entity 'PRELIMINARY EVALUATION' named entity 'INTRODUCTION' named entity 'MONO' named entity 'ADDUCTS' named entity 'ACTIVITY' named entity 'pathogen' named entity 'active' named entity 'evaluated' named entity 'cancer cell' named entity 'secondary amine' named entity 'conjugates' named entity 'cytotoxicity' named entity 'Mannich' named entity '11.3' named entity 'Mannich' named entity 'quinoline' named entity 'dioxane' named entity 'filtrate' named entity 'dose response curve' named entity 'DMSO' named entity 'hydrophobic' named entity 'cancer cell lines' named entity 'isatin' named entity 'Melting Point apparatus' named entity 'C-5' named entity 'substituent' named entity 'moiety' named entity 'PC-3' named entity 'mmol' named entity 'cytotoxic' named entity '5-fluorouracil' named entity 'ethyl acetate' named entity 'DMSO' named entity 'mmol' named entity 'trichomonas' named entity 'chloroform' named entity 'pathogen' named entity 'chemical modification' named entity 'C-5' named entity 'methanol' named entity 'Mannich'

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