About: Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses

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About: Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses
Creator	Irimia, Daniel Alter, Galit Ba, John, St Ryan, Edward Shui, Jessica St, Yu, Xu Edlow, Andrea Bartsch, Yannic Bassett, Ingrid Chiu, Michelle Fischinger, Stephanie Li, Jonathan Neilan, Anne Avino, Paolo Hardcastle, Margot Lerou, Paul Lima, Rosiane Yockey, Laura Yonker, Lael Ab, Patel Appleman, Lori Appleman, Michelle Arya, Puneeta Ba, Grace Bordt, Evan Bonventre, Joseph Bordt, Laura Chiu, Allison De La Flor, Denis De La Flor, Fialkowski De La Flor, Rosiane Fasano, Alessio Ea, Bordt Fialkowski, Allison Fialkowski, Denis Gootkind, Arya Gootkind, Elizabeth Hardcastle, Anita Je, Shui John, Anita John, Lori Jv, Bonventre Lima, Evan Lj, D'avino, Yockey Ml, Chiu Park, Grace Park, Margot Patel, Ankit Ph, Lerou Regan, James Xg, Yu Yockey,
Source	Elsevier; Medline; PMC
abstract	Data sharing: The data obtained as part of this study are available from the corresponding author upon reasonable request. OBJECTIVES: As schools plan for re-opening, understanding the potential role children play in the coronavirus infectious disease 2019 (COVID-19) pandemic and the factors that drive severe illness in children is critical. Study design: Children ages 0-22 years with suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection presenting to urgent care clinics or being hospitalized for confirmed/suspected SARS-CoV-2 infection or multisystem inflammatory syndrome in children (MIS-C) at Massachusetts General Hospital (MGH) were offered enrollment in the MGH Pediatric COVID-19 Biorepository. Enrolled children provided nasopharyngeal, oropharyngeal, and/or blood specimens. SARS-CoV-2 viral load, ACE2 RNA levels, and serology for SARS-CoV-2 were quantified. RESULTS: A total of 192 children (mean age 10.2 +/- 7 years) were enrolled. Forty-nine children (26%) were diagnosed with acute SARS-CoV-2 infection; an additional 18 children (9%) met criteria for MIS-C. Only 25 (51%) of children with acute SARS-CoV-2 infection presented with fever; symptoms of SARS-CoV-2 infection, if present, were non-specific. Nasopharyngeal viral load was highest in children in the first 2 days of symptoms, significantly higher than hospitalized adults with severe disease (P = .002). Age did not impact viral load, but younger children had lower ACE2 expression (P=0.004). IgM and IgG to the receptor binding domain (RBD) of the SARS-CoV-2 spike protein were increased in severe MIS-C (P<0.001), with dysregulated humoral responses observed. CONCLUSION: This study reveals that children may be a potential source of contagion in the SARS-CoV-2 pandemic in spite of milder disease or lack of symptoms, and immune dysregulation is implicated in severe post-infectious MIS-C.
has issue date	2020-08-20(xsd:dateTime)
bibo:doi	10.1016/j.jpeds.2020.08.037
bibo:pmid	32827525
has license	no-cc
sha1sum (hex)	df44bd591c6975c433622e9bfcf4e951c9b0b785
schema:url	https://doi.org/10.1016/j.jpeds.2020.08.037
resource representing a document's title	Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses
has PubMed Central identifier	PMC7438214
has PubMed identifier	32827525
schema:publication	J Pediatr
resource representing a document's body	covid:df44bd591c6975c433622e9bfcf4e951c9b0b785#body_text
is schema:about of	named entity 'protein' named entity 'serology' named entity 'age' named entity 'confirmed' named entity 'SARS-CoV-2' named entity 'met' named entity 'disease' named entity 'ages' named entity 'pandemic' named entity 'illness' named entity 'potential' named entity 'SARS-COV-2' named entity 'MGH' named entity 'severe' named entity 'hospitalized' named entity 'potential' named entity 'inflammatory' named entity '2019' named entity 'SARS-CoV-2' named entity 'oropharyngeal' named entity 'infection' named entity 'virus' named entity 'viral load' named entity 'nasopharynx' named entity 'SARS-CoV-2' named entity 'additional' named entity 'infection' named entity 'total'

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