About: Paramyxovirus F1 protein has two fusion peptides: implications for the mechanism of membrane fusion 1 1 Edited by A. R.Fersht

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About: Paramyxovirus F1 protein has two fusion peptides: implications for the mechanism of membrane fusion 1 1 Edited by A. R.Fersht Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Paramyxovirus F1 protein has two fusion peptides: implications for the mechanism of membrane fusion 1 1 Edited by A. R.Fersht
Creator	Shai, Yechiel Peisajovich, Sergio Samuel, Orit
Source	Elsevier; Medline; PMC
abstract	Abstract Viral fusion proteins contain a highly hydrophobic segment, named the fusion peptide, which is thought to be responsible for the merging of the cellular and viral membranes. Paramyxoviruses are believed to contain a single fusion peptide at the N terminus of the F1 protein. However, here we identified an additional internal segment in the Sendai virus F1 protein (amino acids 214–226) highly homologous to the fusion peptides of HIV-1 and RSV. A synthetic peptide, which includes this region, was found to induce membrane fusion of large unilamellar vesicles, at concentrations where the known N-terminal fusion peptide is not effective. A scrambled peptide as well as several peptides from other regions of the F1 protein, which strongly bind to membranes, are not fusogenic. The functional and structural characterization of this active segment suggest that the F1 protein has an additional internal fusion peptide that could participate in the actual fusion event. The presence of homologous regions in other members of the same family suggests that the concerted action of two fusion peptides, one N-terminal and the other internal, is a general feature of paramyxoviruses.
has issue date	2000-03-10(xsd:dateTime)
bibo:doi	10.1006/jmbi.2000.3543
bibo:pmid	10698638
has license	els-covid
sha1sum (hex)	df383f9c7e70f4301ec575482b2d30d0b6930f97
schema:url	https://doi.org/10.1006/jmbi.2000.3543
resource representing a document's title	Paramyxovirus F1 protein has two fusion peptides: implications for the mechanism of membrane fusion 1 1 Edited by A. R.Fersht
has PubMed Central identifier	PMC7127493
has PubMed identifier	10698638
schema:publication	Journal of Molecular Biology
resource representing a document's body	covid:df383f9c7e70f4301ec575482b2d30d0b6930f97#body_text
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