About: Distinct Patterns of B-Cell Activation and Priming by Natural Influenza Virus Infection Versus Inactivated Influenza Vaccination

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About: Distinct Patterns of B-Cell Activation and Priming by Natural Influenza Virus Infection Versus Inactivated Influenza Vaccination Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Distinct Patterns of B-Cell Activation and Priming by Natural Influenza Virus Infection Versus Inactivated Influenza Vaccination
Creator	García-Sastre, Adolfo He, Xiao-Song Sanyal, Mrinmoy Albrecht, Randy Greenberg, Harry Dekker, Cornelia Davis, Mark Alto, Holmes, Tyson Va, Palo
source	Medline; PMC
abstract	Background. The human B-cell response to natural influenza virus infection has not been extensively investigated at the polyclonal level. Methods. The overall B-cell response of patients acutely infected with the 2009 pandemic influenza A(H1N1)pdm09 virus (A[H1N1]pdm09) was analyzed by determining the reactivity of plasmablast-derived polyclonal antibodies (PPAbs) to influenza proteins. Recipients of inactivated influenza vaccine containing the same A(H1N1)pdm09 strain were studied for comparison. Results. During acute infection, robust plasmablast responses to the infecting virus were detected, characterized by a greater PPAb reactivity to the conserved influenza virus nuclear protein and to heterovariant and heterosubtypic hemagglutinins, in comparison to responses to the inactivated A(H1N1)pdm09 vaccine. In A(H1N1)pdm09 vaccinees, the presence of baseline serum neutralizing antibodies against A(H1N1)pdm09, suggesting previous exposure to natural A(H1N1)pdm09 infection, did not affect the plasmablast response to vaccination, whereas repeated immunization with inactivated A(H1N1)pdm09 vaccine resulted in significantly reduced vaccine-specific and cross-reactive PPAb responses. Conclusions. Natural A(H1N1)pdm09 infection and inactivated A(H1N1)pdm09 vaccination result in very distinct patterns of B-cell activation and priming. These differences are likely to be associated with differences in protective immunity, especially cross-protection against heterovariant and heterosubtypic influenza virus strains.
has issue date	2014-10-21(xsd:dateTime)
bibo:doi	10.1093/infdis/jiu580
bibo:pmid	25336731
has license	bronze-oa
sha1sum (hex)	df1b2547f6f1faf9bb9a757b60c81257bc811938
schema:url	https://doi.org/10.1093/infdis/jiu580
resource representing a document's title	Distinct Patterns of B-Cell Activation and Priming by Natural Influenza Virus Infection Versus Inactivated Influenza Vaccination
has PubMed Central identifier	PMC4366605
has PubMed identifier	25336731
schema:publication	Journal of Infectious Diseases
resource representing a document's body	covid:df1b2547f6f1faf9bb9a757b60c81257bc811938#body_text
is schema:about of	named entity 'INFLUENZA VACCINATION' named entity 'B-CELL ACTIVATION' named entity 'DISTINCT' named entity 'NATURAL' named entity 'PRIMING' named entity 'INFLUENZA VIRUS' named entity 'INACTIVATED' named entity 'VIRUS INFECTION' named entity 'PATTERNS' named entity 'United States' named entity 'B-cell' named entity 'H7N9' named entity 'antigen' named entity 'seropositive' named entity 'influenza' named entity 'vaccination' named entity 'influenza B virus' named entity 'coronavirus' named entity 'A(H1N1)pdm09' named entity 'fluorescent' named entity 'vaccination' named entity 'infection' named entity 'wild-type' named entity 'A(H1N1)pdm09' named entity 'immunization' named entity 'pH1' named entity 'plasmablasts' named entity 'LAIV' named entity 'vaccination' named entity 'A(H1N1)pdm09' named entity 'antigen' named entity 'influenza vaccination' named entity 'IgG' named entity 'plasmablasts' named entity 'immunoglobulin' named entity 'immunization' named entity 'influenza' named entity 'influenza' named entity 'seroconversion' named entity 'seropositive' named entity 'LAIV' named entity 'SAS Institute' named entity 'immunization' named entity 'multiple comparisons' named entity 'influenza virus' named entity 'assay' named entity 'asymptomatic' named entity 'neutralizing antibodies' named entity 'antibody' named entity 'A(H1N1)pdm09' named entity 'immunization' named entity 'influenza virus' named entity 'PCR' named entity 'A(H1N1)pdm09' named entity 'immunization' named entity 'antibody repertoire' named entity 'influenza virus' named entity 'immunization' named entity 'vaccine' named entity 'A(H1N1)pdm09' named entity 'memory B cells' named entity 'nasopharyngeal swab' named entity 'influenza virus' named entity 'infection' named entity 'vaccine' named entity 'monovalent' named entity 'Enzyme-linked immunosorbent assays' named entity 'A(H1N1)pdm09' named entity 'B-cell' named entity 'intradermally' named entity 'Influenza' named entity 'A(H1N1)pdm09'

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