About: Dietary Enterococcus faecium NCIMB 10415 and Zinc Oxide Stimulate Immune Reactions to Trivalent Influenza Vaccination in Pigs but Do Not Affect Virological Response upon Challenge Infection

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About: Dietary Enterococcus faecium NCIMB 10415 and Zinc Oxide Stimulate Immune Reactions to Trivalent Influenza Vaccination in Pigs but Do Not Affect Virological Response upon Challenge Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dietary Enterococcus faecium NCIMB 10415 and Zinc Oxide Stimulate Immune Reactions to Trivalent Influenza Vaccination in Pigs but Do Not Affect Virological Response upon Challenge Infection
Creator	Burwinkel, Michael Blohm, Ulrike Breithaupt, Angele Chai, Weidong Hoffmann, Bernd Janczyk, Pawel Lange, Elke Osterrieder, Nikolaus Pieper, Robert Rieger, Juliane Twardziok, Sven Wang, Zhenya
Source	PMC
abstract	Swine influenza viruses (SIV) regularly cause significant disease in pigs worldwide. Since there is no causative treatment of SIV, we tested if probiotic Enterococcus (E.) faecium NCIMB 10415 or zinc (Zn) oxide as feed supplements provide beneficial effects upon SIV infection in piglets. Seventy-two weaned piglets were fed three different diets containing either E. faecium or different levels of Zn (2500 ppm, Zn(high); 50 ppm, Zn(low)). Half of the piglets were vaccinated intramuscularly (VAC) twice with an inactivated trivalent SIV vaccine, while all piglets were then infected intranasally with H3N2 SIV. Significantly higher weekly weight gains were observed in the E. faecium group before virus infection, and piglets in Zn(high) and E. faecium groups gained weight after infection while those in the control group (Zn(low)) lost weight. Using ELISA, we found significantly higher H3N2-specific antibody levels in the E. faecium+VAC group 2 days before and at the day of challenge infection as well as at 4 and 6 days after challenge infection. Higher hemagglutination inhibition (HI) titers were also observed in the Zn(high)+VAC and E. faecium+VAC groups at 0, 1 and 4 days after infection. However, there were no significant differences in virus shedding and lung lesions between the dietary groups. Using flow cytometry analysis significantly higher activated T helper cells and cytotoxic T lymphocyte percentages in the PBMCs were detected in the Zn(high) and E. faecium groups at single time points after infection compared to the Zn(low) control group, but no prolonged effect was found. In the BAL cells no influence of dietary supplementation on immune cell percentages could be detected. Our results suggest that feeding high doses of zinc oxide and particularly E. faecium could beneficially influence humoral immune responses after vaccination and recovery from SIV infection, but not affect virus shedding and lung pathology.
has issue date	2014-01-28(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0087007
bibo:pmid	24489827
has license	cc-by
sha1sum (hex)	df1017e24101a51f6b5ca30ae2cb8376d8756a61
schema:url	https://doi.org/10.1371/journal.pone.0087007
resource representing a document's title	Dietary Enterococcus faecium NCIMB 10415 and Zinc Oxide Stimulate Immune Reactions to Trivalent Influenza Vaccination in Pigs but Do Not Affect Virological Response upon Challenge Infection
has PubMed Central identifier	PMC3904981
has PubMed identifier	24489827
schema:publication	PLoS One
resource representing a document's body	covid:df1017e24101a51f6b5ca30ae2cb8376d8756a61#body_text
is schema:about of	named entity 'Since' named entity 'SIV' named entity 'recovery' named entity 'infection' named entity 'SIV' named entity 'effects' named entity 'infected' named entity 'PBMCs' named entity 'SIV' named entity 'titers' named entity 'lung' covid:arg/df1017e24101a51f6b5ca30ae2cb8376d8756a61 named entity 'Higher' named entity 'SIV' named entity 'VAC' named entity 'infection' named entity 'specific' named entity 'Madin-Darby canine kidney' named entity 'virus' named entity 'infection' named entity 'immune defense' named entity 'feed additive' named entity '450 nm' named entity 'FACS' named entity 'influenza A virus' named entity 'Friedrich-Loeffler-Institut' named entity 'E. faecium' named entity 'antibody response' named entity 'parenchymal' named entity 'antibody' named entity 'tissue sections' named entity 'infection' named entity 'CD21' named entity 'vaccine' named entity 'weaning' named entity 'memory B cells' named entity 'E. faecium' named entity 'SIV' named entity 'cell sorting' named entity 'cellular immune responses' named entity 'CD8 +' named entity 'Viral' named entity 'BSL3' named entity 'toxic effects' named entity 'weight loss' named entity 'virus' named entity 'piglets' named entity 'feeding' named entity 'infection' named entity 'osmosis' named entity 'culture medium' named entity 'treatment groups' named entity 'lymph nodes' named entity 'antiviral' named entity 'infection' named entity 'SIV' named entity 'B-cell' named entity 'sodium azide' named entity 'ZnO' named entity 'follow-up' named entity 'CD8 +' named entity 'treatment groups' named entity 'BSA' named entity 'Bissendorf' named entity 'CD4' named entity 'blood sample' named entity 'SIV' named entity 'immunostaining' named entity 'Rostock' named entity 'Neuss'

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