About: 2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implications

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About: 2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implications Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implications
Creator	Chang, Tong-Shin Jeong, Woojin Choi, Min Kang, Sang Rhee, Sue
Source	Elsevier; Medline; PMC
abstract	H(2)O(2) is a reactive oxygen species that has drawn much interest because of its role as a second messenger in receptor-mediated signaling. Mammalian 2-Cys peroxiredoxins have been shown to eliminate efficiently the H(2)O(2) generated in response to receptor stimulation. 2-Cys peroxiredoxins are members of a novel peroxidase family that catalyze the H(2)O(2) reduction reaction in the presence of thioredoxin, thioredoxin reductase and NADPH. Several lines of evidence suggest that 2-Cys peroxiredoxins have dual roles as regulators of the H(2)O(2) signal and as defenders of oxidative stress. In particular, 2-Cys peroxiredoxin appears to provide selective, specific and localized control of receptor-mediated signal transduction. Thus, the therapeutic potential of 2-Cys peroxiredoxins is clear for diseases, such as cancer and cardiovascular diseases, that involve reactive oxygen species.
has issue date	2005-11-09(xsd:dateTime)
bibo:doi	10.1016/j.molmed.2005.10.006
bibo:pmid	16290020
has license	no-cc
sha1sum (hex)	dedbce4a087182765828eb2ec40c581e303f2d84
schema:url	https://doi.org/10.1016/j.molmed.2005.10.006
resource representing a document's title	2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implications
has PubMed Central identifier	PMC7185838
has PubMed identifier	16290020
schema:publication	Trends Mol Med
resource representing a document's body	covid:dedbce4a087182765828eb2ec40c581e303f2d84#body_text
is schema:about of	named entity 'Cys' named entity 'THERAPEUTIC' named entity 'PEROXIREDOXIN' named entity 'FUNCTION' named entity 'CYS' named entity 'INTRACELLULAR SIGNAL TRANSDUCTION' named entity 'protein aggregation' named entity 'cysteine' named entity 'neurodegenerative disease' named entity 'transformed cells' named entity 'Mass spectrometric analysis' named entity 'oxidized' named entity 'intracellular signal transduction' named entity 'peroxiredoxin' named entity 'molecular chaperone' named entity 'Cys' named entity 'metabolic processes' named entity 'lipid membrane' named entity 'biomarkers' named entity 'Cys' named entity 'life-threatening diseases' named entity 'neurons' named entity 'sulfoxide' named entity 'chaperone' named entity 'Cys' named entity 'mammals' named entity 'catalase' named entity 'tyrosine' named entity 'N-terminal' named entity 'transcriptional activation' named entity 'RTK' named entity 'peroxiredoxins' named entity 'membrane receptor' named entity 'cytotoxic activity' named entity 'foam cells' named entity 'active site' named entity 'platelets' named entity 'tyrosine phosphorylation' named entity 'Cys' named entity 'Cys' named entity 'Cys' named entity 'treatment of cancer' named entity 'Cys' named entity 'cancer cells' named entity 'catalytic mechanism' named entity 'malignant' named entity 'Cys' named entity 'Rac' named entity 'therapeutic approaches' named entity 'protein-protein interactions' named entity 'exogenously' named entity 'cell proliferation' named entity 'catalase' named entity 'K562' named entity 'recombinant' named entity 'glutathione reductase' named entity 'ROS' named entity 'NADPH' named entity 'NADPH' named entity 'reactive oxygen species' named entity 'early diagnosis' named entity 'anti-viral' named entity 'ROS' named entity 'phosphatidylinositol 3-kinase' named entity 'active site' named entity 'Cys' named entity 'transcriptional activity' named entity 'cervical cancer' named entity 'active site' named entity 'protein aggregation' named entity 'glutathione' named entity 'excitotoxic' named entity 'heme group' named entity 'intracellular' named entity 'Cys' named entity 'Cys' named entity 'arterial wall'

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