About: Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
Creator	Schwartz, Robert Oishi, Kohei Liu, Wen-Chun Albrecht, Randy Jordan, Tristan Lim, Jean Tenoever, Benjamin Blanco-Melo, Daniel Hoagland, Daisy Møller, Rasmus Nilsson-Payant, Benjamin Panis, Maryline Sachs, David Uhl, Skyler Wang, Taia
Source	Elsevier; Medline; PMC
abstract	Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here we offer an in-depth analysis of the transcriptional response to SARS-CoV-2 compared with other respiratory viruses. Cell and animal models of SARS-CoV-2 infection, in addition to transcriptional and serum profiling of COVID-19 patients, consistently revealed a unique and inappropriate inflammatory response. This response is defined by low levels of type I and III interferons juxtaposed to elevated chemokines and high expression of IL-6. We propose that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.
has issue date	2020-05-15(xsd:dateTime)
bibo:doi	10.1016/j.cell.2020.04.026
bibo:pmid	32416070
has license	no-cc
sha1sum (hex)	dea4b05ab91f7eb501a9205c53c2f510bdccf147
schema:url	https://doi.org/10.1016/j.cell.2020.04.026
resource representing a document's title	Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
has PubMed Central identifier	PMC7227586
has PubMed identifier	32416070
schema:publication	Cell
resource representing a document's body	covid:dea4b05ab91f7eb501a9205c53c2f510bdccf147#body_text
is schema:about of	named entity 'viral' named entity 'addition' named entity 'infection' named entity 'SARS-CoV-2' named entity 'vivo' named entity 'induces' named entity 'PRO-' named entity 'IN VIVO' named entity 'IMMINENT' named entity 'SERUM' named entity 'RESPIRATORY VIRUSES' named entity 'Viral' named entity 'This' named entity 'defining' named entity 'IAV' named entity 'viruses' named entity 'pattern recognition receptors' named entity 'SARS-CoV-2' named entity 'IFN' named entity 'respiratory tract' named entity 'biopsies' named entity 'MERS' named entity 'physiological' named entity 'IL-6' named entity 'CXCL9' named entity 'chemokines' named entity 'CXCL9' named entity 'type I' named entity 'host response' named entity 'juxtaposed' named entity 'emergence' named entity 'interferons' named entity 'SARS-CoV-2' named entity 'infection' named entity 'pro-inflammatory' named entity 'infection' named entity 'transcriptional' named entity 'chemokine' named entity 'SARS-CoV-2' named entity 'infection' named entity 'Krammer' named entity 'ACE2' named entity 'IRF9' named entity 'virus infection' named entity 'RNA-seq' named entity 'IFNA10' named entity 'ABCE1' named entity 'inflammatory response' named entity 'plaque assays' named entity 'epithelial' named entity 'virus replication' named entity 'SARS-CoV-2' named entity 'cell culture' named entity 'fever' named entity 'chemokine' named entity 'Western blot' named entity 'IFN' named entity 'SARS-CoV-2' named entity 'LPAR6' named entity 'Calu-3' named entity 'dramatic increase' named entity 'bronchial' named entity 'DHX58' named entity 'ISGs' named entity 'chemokines' named entity 'CXCL8' named entity 'orders of magnitude'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software