About: A regioselective etherification of pyridoxine via an ortho-pyridinone methide intermediate

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About: A regioselective etherification of pyridoxine via an ortho-pyridinone methide intermediate Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A regioselective etherification of pyridoxine via an ortho-pyridinone methide intermediate
Creator	Boyce, Gregory Jiménez, Brian Yazarians, Jessica
Source	Elsevier; Medline; PMC
abstract	Abstract The catalyst-free, regioselective synthesis of 4′-O-substituted pyridoxine derivatives under solventless conditions is described. The methodology relies on the highly regioselective formation of the ortho-pyridinone methide from pyridoxine and subsequent oxa-Michael addition of alcohol nucleophiles. This methodology provides good to excellent yields for primary and secondary alcohols and moderate yields for tertiary alcohols.
has issue date	2017-06-07(xsd:dateTime)
bibo:doi	10.1016/j.tetlet.2017.04.082
bibo:pmid	32287448
has license	els-covid
sha1sum (hex)	de5e4a7ba7cd5f5c385788d311756e9e5b363bc3
schema:url	https://doi.org/10.1016/j.tetlet.2017.04.082
resource representing a document's title	A regioselective etherification of pyridoxine via an ortho-pyridinone methide intermediate
has PubMed Central identifier	PMC7111860
has PubMed identifier	32287448
schema:publication	Tetrahedron Letters
resource representing a document's body	covid:de5e4a7ba7cd5f5c385788d311756e9e5b363bc3#body_text
is schema:about of	named entity 'PYRIDINONE' named entity 'methodology' named entity 'ORTHO-' named entity 'DESCRIBED' named entity 'METHODOLOGY' named entity 'PRIMARY' named entity 'SUBSEQUENT' named entity 'PYRIDOXINE' named entity 'INTERMEDIATE' named entity 'MODERATE' named entity 'GOOD' named entity 'NUCLEOPHILES' named entity 'ETHERIFICATION' named entity 'OXA' named entity 'SECONDARY ALCOHOLS' named entity 'ALCOHOL' named entity 'EXCELLENT' named entity 'FREE' named entity 'TERTIARY ALCOHOLS' named entity 'PROVIDES' named entity 'FORMATION' named entity 'HIGHLY' named entity 'SYNTHESIS' named entity 'PYRIDOXINE' named entity 'CATALYST' named entity 'CONDITIONS' named entity 'MICHAEL ADDITION' covid:arg/de5e4a7ba7cd5f5c385788d311756e9e5b363bc3 named entity 'formation' named entity 'secondary alcohols' named entity 'tertiary' named entity 'alcohol' named entity 'pyridoxine' named entity 'pyridoxine' named entity 'Michael addition' named entity 'secondary alcohols' named entity 'pyridoxine' named entity 'pyridoxine' named entity 'ortho' named entity 'This' named entity 'steric' named entity 'reaction time' named entity 'natural product' named entity 'pyridoxamine' named entity 'solubility' named entity 'ortho' named entity 'Pyridoxine' named entity 'isoamyl alcohol' named entity 'quinone methide' named entity 'cofactor' named entity 'n-butanol' named entity 'viral replication' named entity 'primary alcohols' named entity 'Lewis acid' named entity 'organic solvents' named entity 'primary alcohols' named entity 'antibiotics' named entity 'pyridoxine' named entity 'n-butanol' named entity 'ether' named entity 'microwave-assisted synthesis' named entity 'high temperatures' named entity 'isoniazid' named entity 'boronic acid' named entity 'ether' named entity 'pyridoxine' named entity 'ginkgotoxin' named entity 'p-toluenesulfonic acid' named entity 'protic solvents' named entity 'alcohols' named entity 'ether' named entity 'functional group' named entity 'ginkgotoxin' named entity 'steric' named entity 'organic solvent' named entity 'toxicological studies' named entity 'ginkgotoxin' named entity 'Sigma-Aldrich' named entity 'pyridinone'

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