About: Serological Profiling of a Candida albicans Protein Microarray Reveals Permanent Host-Pathogen Interplay and Stage-Specific Responses during Candidemia

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About: Serological Profiling of a Candida albicans Protein Microarray Reveals Permanent Host-Pathogen Interplay and Stage-Specific Responses during Candidemia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Serological Profiling of a Candida albicans Protein Microarray Reveals Permanent Host-Pathogen Interplay and Stage-Specific Responses during Candidemia
Creator	Clancy, C Kayala, M Mochon, A Wingard, J Ye, J
Source	PMC
abstract	Candida albicans in the immunocompetent host is a benign member of the human microbiota. Though, when host physiology is disrupted, this commensal-host interaction can degenerate and lead to an opportunistic infection. Relatively little is known regarding the dynamics of C. albicans colonization and pathogenesis. We developed a C. albicans cell surface protein microarray to profile the immunoglobulin G response during commensal colonization and candidemia. The antibody response from the sera of patients with candidemia and our negative control groups indicate that the immunocompetent host exists in permanent host-pathogen interplay with commensal C. albicans. This report also identifies cell surface antigens that are specific to different phases (i.e. acute, early and mid convalescence) of candidemia. We identified a set of thirteen cell surface antigens capable of distinguishing acute candidemia from healthy individuals and uninfected hospital patients with commensal colonization. Interestingly, a large proportion of these cell surface antigens are involved in either oxidative stress or drug resistance. In addition, we identified 33 antigenic proteins that are enriched in convalescent sera of the candidemia patients. Intriguingly, we found within this subset an increase in antigens associated with heme-associated iron acquisition. These findings have important implications for the mechanisms of C. albicans colonization as well as the development of systemic infection.
has issue date	2010-03-26(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1000827
bibo:pmid	20361054
has license	cc0
sha1sum (hex)	de33cc55be6bb27a8f52e33fe21836c670252e28
schema:url	https://doi.org/10.1371/journal.ppat.1000827
resource representing a document's title	Serological Profiling of a Candida albicans Protein Microarray Reveals Permanent Host-Pathogen Interplay and Stage-Specific Responses during Candidemia
has PubMed Central identifier	PMC2845659
has PubMed identifier	20361054
schema:publication	PLoS Pathog
resource representing a document's body	covid:de33cc55be6bb27a8f52e33fe21836c670252e28#body_text
is schema:about of	named entity 'UNINFECTED' named entity 'DEVELOPMENT' named entity 'DIFFERENT' named entity 'NEGATIVE CONTROL' named entity 'CAPABLE' named entity 'MICROBIOTA' named entity 'DISRUPTED' named entity 'IRON ACQUISITION' named entity 'DYNAMICS' named entity 'INTERACTION' named entity '28I' named entity 'COMMENSAL' named entity 'CONTROL GROUPS' named entity 'THIRTEEN' named entity 'THESE' named entity 'PATHOGENESIS' named entity 'EARLY' named entity 'REPORT' named entity 'PATIENTS' named entity 'IMMUNOGLOBULIN G' named entity 'STAGE' named entity 'REVEALS' named entity 'cell' named entity 'thirteen' named entity 'surface' named entity 'development' named entity 'individuals' named entity 'sera' named entity 'pathogenesis' named entity 'candidemia' named entity 'surface' named entity 'Interplay' named entity 'Profiling' named entity 'SPECIFIC' named entity 'PATHOGEN' named entity 'ADDITION' named entity 'PROTEIN MICROARRAY' named entity 'SYSTEMIC INFECTION' named entity 'PHYSIOLOGY' named entity 'ASSOCIATED WITH' named entity 'HAVE' named entity 'ENRICHED' named entity 'BENIGN' named entity 'DISTINGUISHING' named entity 'HOSPITAL PATIENTS' named entity 'CANDIDA ALBICANS' named entity 'PERMANENT' named entity 'PATHOGEN' named entity 'ANTIGENS' named entity 'CONVALESCENT' named entity 'SET' named entity 'SPECIFIC' named entity 'IMMUNOCOMPETENT' named entity 'LITTLE' named entity 'INDIVIDUALS' named entity 'FINDINGS' named entity 'CELL SURFACE ANTIGENS' named entity 'PROTEINS' named entity 'ASSOCIATED' named entity 'OPPORTUNISTIC INFECTION' named entity 'PERMANENT' named entity 'CANDIDEMIA' named entity 'RESPONSES' named entity 'SEROLOGICAL' named entity 'PROTEIN MICROARRAY' named entity 'INCREASE' named entity 'HUMAN' named entity 'CANDIDEMIA' named entity 'KNOWN' named entity 'HOST' named entity 'EITHER' named entity 'IS A' named entity 'PHASES' named entity 'PROPORTION' named entity 'SUBSET' named entity 'DRUG RESISTANCE' named entity 'LARGE'

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