About: Fibrinolytic niche is requested for alveolar type 2 cell-mediated alveologenesis and injury repair

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About: Fibrinolytic niche is requested for alveolar type 2 cell-mediated alveologenesis and injury repair Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Fibrinolytic niche is requested for alveolar type 2 cell-mediated alveologenesis and injury repair
Creator	Ji, Hong-Long Fang, Xiaohui Matthay, Michael Chang, Jianjun Gibran, Ali Ikebe, Mistuo Jain, Krishan Jiang, Dianhua Komatsu, Satoshi Liang, Jiurong Zhang, Mo Zhao, Runzhen Zhou, Beiyun Edu, James
Source	BioRxiv
abstract	COVID-19, SARS, and MERS are featured by fibrinolytic dysfunction. To test the role of the fibrinolytic niche in the regeneration of alveolar epithelium, we compared the self-renewing capacity of alveolar epithelial type 2 (AT2) cells and its differentiation to AT1 cells between wild type (wt) and fibrinolytic niche deficient mice (Plau−/− and Serpine1Tg). A significant reduction in both proliferation and differentiation of deficient AT2 cells was observed in vivo and in 3D organoid cultures. This decrease was mainly restored by uPA derived A6 peptide, a binding fragment to CD44 receptors. The proliferative and differential rate of CD44+ AT2 cells was greater than that of CD44− controls. There was a reduction in transepithelial ion transport in deficient monolayers compared to wt cells. Moreover, we found a marked suppression in total AT2 cells and CD44+ subpopulation in lungs from brain dead patients with acute respiratory distress syndrome (ARDS) and a mouse model infected by influenza viruses. Thus, we demonstrate that the fibrinolytic niche can regulate AT2-mediated homeostasis and regeneration via a novel uPA-A6-CD44+-ENaC cascade.
has issue date	2020-03-25(xsd:dateTime)
bibo:doi	10.1101/2020.03.24.006270
has license	biorxiv
sha1sum (hex)	de1f46387f76cec40f588d61832e3acbf2088707
schema:url	https://doi.org/10.1101/2020.03.24.006270
resource representing a document's title	Fibrinolytic niche is requested for alveolar type 2 cell-mediated alveologenesis and injury repair
schema:publication	bioRxiv
resource representing a document's body	covid:de1f46387f76cec40f588d61832e3acbf2088707#body_text
is schema:about of	named entity 'reduction' named entity 'AT2' named entity 'CD44' named entity 'infected' named entity 'peptide' named entity 'epithelium' named entity 'cells' named entity 'cultures' named entity 'niche' named entity 'CD44' named entity 'CD44' named entity 'transport' named entity 'cascade' named entity 'MERS' named entity 'cells' named entity 'organoid' named entity 'homeostasis' named entity 'CD44' named entity 'AT2' named entity 'CD44' named entity 'peptide' named entity 'alveolar' named entity 'type 2' named entity 'organoids' named entity 'ENaC' named entity 'organoids' named entity 'bovine serum albumin' named entity 'muscle' named entity 'CD44' named entity 'fibrinolytic' named entity 'cell sorting' named entity 'EdU' named entity 't-tests' named entity 'epithelial lining' named entity 'progenitor cells' named entity 'amiloride' named entity 'CD44' named entity 'CD44' named entity 'Serpine1' named entity 'H1N1' named entity 'plasma membrane' named entity 'FACS' named entity 'Fluorescent' named entity 'alveolar' named entity 'multiple comparisons' named entity 'systemic diseases' named entity 'negative regulator' named entity 'influenza' named entity 'organoid' named entity 'cell proliferation' named entity 'mice' named entity 'culture medium' named entity 'digestive enzymes' named entity 'organoids' named entity 'ISC' named entity 'DAPI' named entity 'lungs' named entity 'epithelial' named entity 'Plau' named entity 'antibodies' named entity 'motif' named entity 'surface area' named entity 'type 2' named entity 'ImageJ' named entity 'lungs' named entity 'Normality tests' named entity 'hamster' named entity 'pre-clinical' named entity 'one-way ANOVA' named entity 'centrifuged' named entity 'fibrinolytic'

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