About: Expected immune recognition of COVID-19 virus by memory from earlier infections with common coronaviruses in a large part of the world population

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About: Expected immune recognition of COVID-19 virus by memory from earlier infections with common coronaviruses in a large part of the world population Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Expected immune recognition of COVID-19 virus by memory from earlier infections with common coronaviruses in a large part of the world population
Creator	Smith, David Gil, Anna Selin, Liisa Dijkstra, Johannes Hashimoto, Keiichiro Jm, Dijkstra
topic	covid:ddfb9792224ce1cec3356bcc5d119cc578c0a407#this
Source	PMC
abstract	SARS-CoV-2 is the coronavirus agent of the COVID-19 pandemic causing high mortalities. In contrast, the widely spread human coronaviruses OC43, HKU1, 229E, and NL63 tend to cause only mild symptoms. The present study shows, by in silico analysis, that these common human viruses are expected to induce immune memory against SARS-CoV-2 by sharing protein fragments (antigen epitopes) for presentation to the immune system by MHC class I. A list of such epitopes is provided. The number of these epitopes and the prevalence of the common coronaviruses suggest that a large part of the world population has some degree of specific immunity against SARS-CoV-2 already, even without having been infected by that virus. For inducing protection, booster vaccinations enhancing existing immunity are less demanding than primary vaccinations against new antigens. Therefore, for the discussion on vaccination strategies against COVID-19, the available immune memory against related viruses should be part of the consideration.
has issue date	2020-04-23(xsd:dateTime)
bibo:doi	10.12688/f1000research.23458.1
has license	cc-by
sha1sum (hex)	ddfb9792224ce1cec3356bcc5d119cc578c0a407
schema:url	https://doi.org/10.12688/f1000research.23458.1
resource representing a document's title	Expected immune recognition of COVID-19 virus by memory from earlier infections with common coronaviruses in a large part of the world population
has PubMed Central identifier	PMC7309412
schema:publication	F1000Res
resource representing a document's body	covid:ddfb9792224ce1cec3356bcc5d119cc578c0a407#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/ddfb9792224ce1cec3356bcc5d119cc578c0a407
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