About: Deciphering the biology of porcine epidemic diarrhea virus in the era of reverse genetics

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Deciphering the biology of porcine epidemic diarrhea virus in the era of reverse genetics
Creator	Chailangkarn, Thanathom Jongkaewwattana, Anan Koonpaew, Surapong Teeravechyan, Samaporn Jaru-Ampornpan, Peera Wongthida, Phonphimon Namprachan Frantz, Phanramphoei
Source	Elsevier; Medline; PMC
abstract	Abstract Emergence of the porcine epidemic diarrhea virus (PEDV) as a global threat to the swine industry underlies the urgent need for deeper understanding of this virus. To date, we have yet to identify functions for all the major gene products, much less grasp their implications for the viral life cycle and pathogenic mechanisms. A major reason is the lack of genetic tools for studying PEDV. In this review, we discuss the reverse genetics approaches that have been successfully used to engineer infectious clones of PEDV as well as other potential and complementary methods that have yet to be applied to PEDV. The importance of proper cell culture for successful PEDV propagation and maintenance of disease phenotype are addressed in our survey of permissive cell lines. We also highlight areas of particular relevance to PEDV pathogenesis and disease that have benefited from reverse genetics studies and pressing questions that await resolution by such studies. In particular, we examine the spike protein as a determinant of viral tropism, entry and virulence, ORF3 and its association with cell culture adaptation, and the nucleocapsid protein and its potential role in modulating PEDV pathogenicity. Finally, we conclude with an exploration of how reverse genetics can help mitigate the global impact of PEDV by addressing the challenges of vaccine development.
has issue date	2016-12-02(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2016.05.003
bibo:pmid	27212685
has license	els-covid
sha1sum (hex)	dde5e45068257cc6ceab9b99a861a6608bb53885
schema:url	https://doi.org/10.1016/j.virusres.2016.05.003
resource representing a document's title	Deciphering the biology of porcine epidemic diarrhea virus in the era of reverse genetics
has PubMed Central identifier	PMC7114553
has PubMed identifier	27212685
schema:publication	Virus Research
resource representing a document's body	covid:dde5e45068257cc6ceab9b99a861a6608bb53885#body_text
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