About: Elevated serum levels of decoy receptor 3 are associated with disease severity in patients with hemorrhagic fever with renal syndrome

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About: Elevated serum levels of decoy receptor 3 are associated with disease severity in patients with hemorrhagic fever with renal syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Elevated serum levels of decoy receptor 3 are associated with disease severity in patients with hemorrhagic fever with renal syndrome
Creator	Li, Man Xie, Ming Dai, • Dong, Yanying Shi, Dongsha Wang, Xiangling
Source	PMC
abstract	Hemorrhagic fever with renal syndrome (HFRS) is an acute viral infectious disease characterized by fever, hemorrhage and renal failure. HFRS has become a serious public health problem in China. Unfortunately, the pathogenesis of HFRS has not been completely clarified. The aim of this study is to investigate the changes of decoy receptor 3 (DcR3) and to further explore its potential roles in HFRS. The levels of serum DcR3 were measured by sandwich ELISA. We found serum DcR3 levels increased significantly, which reached peak value during the oliguric phase and in the critical group. Moreover, serum DcR3 levels were closely related to the levels of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and parameters reflecting kidney injury including BUN, creatinine (Cr) and proteinuria. This study indicates that high levels of serum DcR3 have associations with the disease stages, severity and degree of kidney damage. Meanwhile, our results suggest that DcR3 may play a dual role in HFRS pathogenesis. First, DcR3 is involved in the inflammatory cascade response resulting in capillary permeability and kidney injury in the early stage. Secondly, HTNV infection induced DcR3 expression at the convalescent phase may act as a feed-back mechanism in anti-inflammatory response. Thus, a study of DcR3 is essential for a better understanding of HFRS pathogenesis.
has issue date	2015-02-03(xsd:dateTime)
bibo:doi	10.1007/s11739-015-1195-7
bibo:pmid	25647584
has license	no-cc
sha1sum (hex)	ddd04a42fdce65bebad91ef38635aefd5a197196
schema:url	https://doi.org/10.1007/s11739-015-1195-7
resource representing a document's title	Elevated serum levels of decoy receptor 3 are associated with disease severity in patients with hemorrhagic fever with renal syndrome
has PubMed Central identifier	PMC7101622
has PubMed identifier	25647584
schema:publication	Intern Emerg Med
resource representing a document's body	covid:ddd04a42fdce65bebad91ef38635aefd5a197196#body_text
is schema:about of	named entity 'reached' named entity 'TNF-a' named entity 'group' named entity 'investigate' named entity 'tumor' named entity 'Elevated' named entity 'serum' named entity 'RESULTING IN' named entity 'LEVELS' named entity 'MECHANISM' named entity 'GROUP' named entity 'kidney' named entity 'oliguric' named entity 'study' named entity 'essential' named entity 'First' named entity 'injury' named entity 'hemorrhage' named entity 'infection' named entity 'hemorrhagic fever' named entity 'hemorrhage' named entity 'oliguric' named entity 'inflammatory cascade' named entity 'decoy receptor 3' named entity 'HFRS' named entity 'kidney injury' named entity 'pro-inflammatory cytokines' named entity 'pathogenesis' named entity 'public health' named entity 'renal failure' named entity 'DcR3' named entity 'HFRS' named entity 'pathogenesis' named entity 'DcR3' named entity 'BUN' named entity 'tumor necrosis factor' named entity 'kidney damage' named entity 'hemorrhagic fever with renal syndrome' named entity 'necrosis' named entity 'kidney damage' named entity 'DcR3' named entity 'heart failure' named entity '0.01' named entity 'serum' named entity 'DcR3' named entity 'asthma' named entity 'infection' named entity 'conjunctival' named entity 'normal distribution' named entity 'DcR3' named entity 'Blood samples' named entity 'DcR3' named entity 'capillary permeability' named entity 'FasL' named entity 'serum' named entity 'DcR3' named entity 'rank correlation' named entity 'one-way ANOVA' named entity '450 nm' named entity 'capillary leak syndrome' named entity 'clinical symptoms' named entity 'antibody' named entity 'dendritic cells' named entity 'China' named entity 'pathogenesis' named entity 'complement' named entity 'kidney function' named entity 'standard curve' named entity 'normal distribution' named entity 'DcR3' named entity 'HFRS' named entity 'serum' named entity 'systolic blood pressure' named entity 'HTNV' named entity 'statistical significance' named entity 'kidneys'

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