About: Population-wide evolution of SARS-CoV-2 immunity tracked by a ternary immunoassay

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About: Population-wide evolution of SARS-CoV-2 immunity tracked by a ternary immunoassay Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Population-wide evolution of SARS-CoV-2 immunity tracked by a ternary immunoassay
Creator	Owens, Ray Ban, Nenad Guo, Jingjing Aguzzi, Adriano Mongkolsapaya, Juthathip Screaton, Gavin Hacker, David Stuart, David Xenarios, Ioannis Lau, Kelvin Liu, Feimei Pojer, Florence Ring, Aaron Schneider, Matthias Boyman, Onur Cervia, Carlo Nilsson, Jakob Schaer, Dominik Burgess-Brown, Nicola Carrella, Alessandra De Cecco, Elena Domange, Julie Doğançay, Berre Dubach, Irina Eb-Ner, Daniel Emmenegger, Marc Frey, Beat Gonzalez-Guerra, Andres Gottschalk, Jochen Hatch, Stephanie Hornemann, Simone Huck, John Imeri, Marigona Jacquat, Raphaël Knowles, Tuomas Kosmoliaptsis, Vasilis Lamparter, David Malinauskas, Tomas Marino, Jacopo Meisl, Georg Moos, Rita Morales, Itzel Probst-Müller, Elsbeth Reimann, Regina Saleh, Lanja Schertler, Gebhard Schneider, Dezirae Schu-Bert 13, Katharina Trevisan, Chiara Tsai, Ching-Ju Von Eckardstein, Arnold Wiedmer, Anne Xu, Catherine Zografou, Chryssa
Source	MedRxiv
abstract	Serological assays can detect anti-SARS-CoV-2 (SARS2) antibodies, but their sensitivity often comes at the expense of specificity. Here we used a Ternary Automated Blood Im-munoassay (TRABI) to assess the IgG response against SARS2 in 3,815 prepandemic plasma samples and 126 virologically and/or clinically confirmed COVID-19 samples. Posterior probabilities were calculated from 3x8 measurements of logarithmically diluted samples against the ectodomain and the receptor-binding domain of the spike protein and the nucleoprotein. We then performed 429,624 assays on 17,901 blood samples from patients of the University Hospital Zurich and from healthy blood donors. We found se-ropositivity in 44 of 8,591 patients and in 26 of 5,388 blood donors from December 2019 to May 2020. Western blotting confirmed seropositivity in COVID samples but in none of the prepandemic samples. Solution-equilibrium measurements revealed immunodominant antibodies with nanomolar affinity in COVID samples, whereas prepandemic plasma showed lower affinities despite similar titers for individual SARS2 antigens. Hence, TRABI identifies seropositive individuals in large unselected cohorts, discriminates be-tween SARS2 immunity and low-affinity crossreactivity, and is therefore suitable for large-scale nationwide screening campaigns.
has issue date	2020-06-02(xsd:dateTime)
bibo:doi	10.1101/2020.05.31.20118554
has license	medrxiv
sha1sum (hex)	dcf57e3a2951cde19d67d8078f9828e786f23d62
schema:url	https://doi.org/10.1101/2020.05.31.20118554
resource representing a document's title	Population-wide evolution of SARS-CoV-2 immunity tracked by a ternary immunoassay
resource representing a document's body	covid:dcf57e3a2951cde19d67d8078f9828e786f23d62#body_text
is schema:about of	named entity 'PLASMA' named entity 'ASSESS' named entity 'IMMUNOASSAY' named entity '27901' named entity 'BLOOD DONORS' named entity 'PATIENTS' named entity 'CONFIRMED' named entity 'UNIVERSITY HOSPITAL' named entity 'SENSITIVITY' named entity 'SARS-COV-2' named entity 'HEALTHY' named entity 'LARGE' named entity 'REVEALED' named entity 'BLOOD' named entity 'SPIKE PROTEIN' named entity 'FOUND' named entity 'DECEMBER' named entity 'seropositivity' named entity 'TRABI' named entity 'plasma' named entity 'COVID' named entity 'plasma' named entity 'antibodies' named entity 'seropositivity' named entity 'SARS2' named entity 'spike protein' named entity 'ectodomain' named entity 'antigens' named entity 'SARS2' named entity 'SARS2' named entity 'immunoassay' named entity 'SARS-CoV-2'

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