About: Collard and cauliflower as a base for production of recombinant antigens

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Collard and cauliflower as a base for production of recombinant antigens
Creator	Koprowski, Hilary Bandurska, Katarzyna Brodzik, Robert Golovkin, Maxim Markley, Karen Pogrebnyak, Natalia Smirnov, Yuriy
Source	Elsevier; PMC
abstract	Abstract Plants have emerged as a modern production system to produce recombinant proteins—antigens that can be used as subunit vaccines. The ideal plant candidate for this purpose should be capable to sustain high levels of expression of foreign proteins without adverse effects on its growth and development. It is also essential that it has large biomass, is edible and suitable for long-term storage and delivery. This work is a part of an effort to develop Cruciferae-based production system using transgenic vegetable plants collard and cauliflower. Several parameters were tested and optimized to achieve an efficient stable transformation of these recalcitrant species with constructs containing expression cassettes for the known viral antigens. Using the original procedure we obtained transgenic collard cv Morris Heading that express high levels of smallpox vaccine candidate (B5) in leaves and retain its normal phenotype. Transgenic cauliflower plants cv Early Snowball were obtained in similar procedure and have shown detectable amounts of SARS coronavirus spike-protein (SARS-CoV S1) in floret tissue of mature curd. To our knowledge, this is the first report on generation of transgenic collard plants ever and the first successful attempt to use these vegetables for production of pharmaceutical proteins.
has issue date	2006-12-31(xsd:dateTime)
bibo:doi	10.1016/j.plantsci.2006.06.017
has license	els-covid
sha1sum (hex)	dced76983861e1bb7a73bf0c54549922c7e07950
schema:url	https://doi.org/10.1016/j.plantsci.2006.06.017
resource representing a document's title	Collard and cauliflower as a base for production of recombinant antigens
has PubMed Central identifier	PMC7114678
schema:publication	Plant Science
resource representing a document's body	covid:dced76983861e1bb7a73bf0c54549922c7e07950#body_text
is schema:about of	named entity 'produce' named entity 'recombinant' named entity 'SYSTEM' named entity 'SUBUNIT VACCINES' named entity 'EXPRESSION' named entity 'PLANTS' named entity 'LONG-TERM' named entity 'EDIBLE' named entity 'TO PRODUCE' named entity 'PROTEINS' named entity 'PLANT' named entity 'HIGH' named entity 'SUITABLE' named entity 'ANTIGENS' named entity 'ESSENTIAL' named entity 'ITS' named entity 'ADVERSE EFFECTS' named entity 'CAPABLE' named entity 'PURPOSE' named entity 'HAVE' named entity 'PRODUCTION' named entity 'ANTIGENS' named entity 'BASE' named entity 'CAULIFLOWER' named entity 'RECOMBINANT' named entity 'STORAGE' named entity 'USED' named entity 'LEVELS' named entity 'FOREIGN' named entity 'IDEAL' named entity 'GROWTH AND DEVELOPMENT' named entity 'DELIVERY' named entity 'BIOMASS' named entity 'PRODUCTION' named entity 'RECOMBINANT PROTEINS' named entity 'CANDIDATE' named entity 'SUSTAIN' named entity 'LARGE' covid:arg/dced76983861e1bb7a73bf0c54549922c7e07950 named entity 'production' named entity 'proteins' named entity 'antigens' named entity 'adverse effects' named entity 'cauliflower' named entity 'cauliflower' named entity 'transgenic' named entity 'viral antigens' named entity 'transgenic' named entity 'primers' named entity 'PCR' named entity 'cauliflower' named entity 'Agrobacterium' named entity 'transgenic' named entity 'PCR' named entity 'extracellular' named entity 'Abgent' named entity 'Arabidopsis' named entity 'gene' named entity 'transgenic plants' named entity 'SARS' named entity 'production of recombinant proteins' named entity 'recombinant proteins' named entity 'acetosyringone' named entity 'antibodies' named entity 'SARS' named entity 'long-term' named entity 'rabies' named entity 'cauliflower' named entity 'antigen' named entity 'Agrobacterium' named entity 'terpenes' named entity 'necrosis' named entity 'targeting signals' named entity 'St. Louis' named entity 'isothiocyanates' named entity 'Transgenic plants' named entity 'genetic elements'

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