About: Effect of Graphene Family Materials on Multiple Myeloma and Non-Hodgkin’s Lymphoma Cell Lines

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About: Effect of Graphene Family Materials on Multiple Myeloma and Non-Hodgkin’s Lymphoma Cell Lines Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effect of Graphene Family Materials on Multiple Myeloma and Non-Hodgkin’s Lymphoma Cell Lines
Creator	Chwalibog, André Grodzik, Marta Gutiérrez, Norma Isidro, Isabel Jaworski, Sławomir Koczoń, Piotr Misiewicz-Krzemińska, Irena Rojas, Elizabeta Sawosz, Ewa Strojny, Barbara
Source	PMC
abstract	The interest around the graphene family of materials is constantly growing due to their potential application in biomedical fields. The effect of graphene and its derivatives on cells varies amongst studies depending on the cell and tissue type. Since the toxicity against non-adherent cell lines has barely been studied, we investigated the effect of graphene and two different graphene oxides against four multiple myeloma cell lines, namely KMS-12-BM, H929, U226, and MM.1S, as well as two non-Hodgkin lymphoma cells lines, namely KARPAS299 and DOHH-2. We performed two types of viability assays, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide conversion) and ATP (adenosine triphosphate detection), flow cytometry analysis of apoptosis induction and cell cycle, cell morphology, and direct interaction analysis using two approaches—visualization of living cells by two different systems, and visualization of fixed and dyed cells. Our results revealed that graphene and graphene oxides exhibit low to moderate cytotoxicity against cells, despite visible interaction between the cells and graphene oxide. This creates possibilities for the application of the selected graphene materials for drug delivery systems or theragnostics in hematological malignancies; however, further detailed studies are necessary to explain the nature of interactions between the cells and the materials.
has issue date	2020-08-03(xsd:dateTime)
bibo:doi	10.3390/ma13153420
bibo:pmid	32756412
has license	cc-by
sha1sum (hex)	dca12728182107f40c7e34a928175d694752a3a9
schema:url	https://doi.org/10.3390/ma13153420
resource representing a document's title	Effect of Graphene Family Materials on Multiple Myeloma and Non-Hodgkin’s Lymphoma Cell Lines
has PubMed Central identifier	PMC7436021
has PubMed identifier	32756412
schema:publication	Materials (Basel)
resource representing a document's body	covid:dca12728182107f40c7e34a928175d694752a3a9#body_text
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