About: Identification of a Novel Polyomavirus from Patients with Acute Respiratory Tract Infections

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About: Identification of a Novel Polyomavirus from Patients with Acute Respiratory Tract Infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of a Novel Polyomavirus from Patients with Acute Respiratory Tract Infections
Creator	Wang, David Nissen, Michael Sloots, Theo Storch, Gregory Whiley, David Wu, Guang Gaynor, Anne Lambert, Stephen Mackay, Ian Brennan, Daniel
Source	Medline; PMC
abstract	We report the identification of a novel polyomavirus present in respiratory secretions from human patients with symptoms of acute respiratory tract infection. The virus was initially detected in a nasopharyngeal aspirate from a 3-year-old child from Australia diagnosed with pneumonia. A random library was generated from nucleic acids extracted from the nasopharyngeal aspirate and analyzed by high throughput DNA sequencing. Multiple DNA fragments were cloned that possessed limited homology to known polyomaviruses. We subsequently sequenced the entire virus genome of 5,229 bp, henceforth referred to as WU virus, and found it to have genomic features characteristic of the family Polyomaviridae. The genome was predicted to encode small T antigen, large T antigen, and three capsid proteins: VP1, VP2, and VP3. Phylogenetic analysis clearly revealed that the WU virus was divergent from all known polyomaviruses. Screening of 2,135 patients with acute respiratory tract infections in Brisbane, Queensland, Australia, and St. Louis, Missouri, United States, using WU virus–specific PCR primers resulted in the detection of 43 additional specimens that contained WU virus. The presence of multiple instances of the virus in two continents suggests that this virus is geographically widespread in the human population and raises the possibility that the WU virus may be a human pathogen.
has issue date	2007-05-04(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.0030064
bibo:pmid	17480120
has license	cc-by
sha1sum (hex)	dc7809e3cbcc5bb53b481641f6796891f4ecedc4
schema:url	https://doi.org/10.1371/journal.ppat.0030064
resource representing a document's title	Identification of a Novel Polyomavirus from Patients with Acute Respiratory Tract Infections
has PubMed Central identifier	PMC1864993
has PubMed identifier	17480120
schema:publication	PLoS Pathog
resource representing a document's body	covid:dc7809e3cbcc5bb53b481641f6796891f4ecedc4#body_text
is schema:about of	named entity 'Missouri' named entity 'genomic' named entity 'pneumonia' named entity 'DNA sequencing' named entity 'detection' named entity 'Identification' named entity 'human' named entity 'virus' named entity 'Citation' named entity 'high' named entity 'specimens' named entity 'Nissen' named entity 'secretions' named entity 'cloned' named entity 'identification' named entity 'T antigen' named entity 'genome' named entity 'respiratory tract infections' named entity 'Australia' named entity 'polyomaviruses' named entity 'WU virus' named entity 'St. Louis' named entity 'Missouri' named entity 'Polyomavirus' named entity 'capsid' named entity 'WU virus' named entity 'protein products' named entity 'nasopharyngeal aspirate' named entity 'polyomaviruses' named entity 'nucleic acid' named entity 'LTAg' named entity 'PCR' named entity 'Polyomaviridae' named entity 'urinary tract disorders' named entity 'respiratory disease' named entity 'kidneys' named entity 'phylogenetic relationship' named entity 'KI virus' named entity 'multiple sequence alignment' named entity 'viruses' named entity 'bone marrow transplant' named entity 'polyoma' named entity 'VP2' named entity 'ATPase' named entity 'homology' named entity 'infection' named entity 'viruses' named entity 'antenatal' named entity 'C-terminal' named entity 'amino acid' named entity 'agnoprotein' named entity 'seroconversion' named entity 'human bocavirus' named entity 'lungs' named entity 'Brisbane' named entity 'renal transplant' named entity 'hamster' named entity 'subclass' named entity 'tumor suppressor' named entity 'KI virus' named entity 'Nucleic acid' named entity 'coronaviruses' named entity 'VP2' named entity 'homology' named entity 'Urine' named entity 'stop codon' named entity 'hypertension' named entity 'protein' named entity 'slightly larger' named entity 'WU virus' named entity 'antigenic' named entity 'WU virus'

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