About: Virulence, pathology, and pathogenesis of Pteropine orthoreovirus (PRV) in BALB/c mice: Development of an animal infection model for PRV

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About: Virulence, pathology, and pathogenesis of Pteropine orthoreovirus (PRV) in BALB/c mice: Development of an animal infection model for PRV Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Virulence, pathology, and pathogenesis of Pteropine orthoreovirus (PRV) in BALB/c mice: Development of an animal infection model for PRV
Creator	Fukushi, Shuetsu Nagata, Noriyo Saijo, Masayuki Taniguchi, Satoshi Watanabe, Shumpei Shimojima, Masayuki Tani, Hideki Egawa, Kazutaka Kurosu, Takeshi Yoshikawa, Tomoki
topic	covid:dc502e4494d5ef1e5a2f54b5df88e7c391d9a763#this
Source	Medline; PMC
abstract	BACKGROUND: Cases of acute respiratory tract infection caused by Pteropine orthoreovirus (PRV) of the genus Orthoreovirus (family: Reoviridae) have been reported in Southeast Asia, where it was isolated from humans and bats. It is possible that PRV-associated respiratory infections might be prevalent in Southeast Asia. The clinical course of PRV is not fully elucidated. METHODS: The virulence, pathology, and pathogenesis of two PRV strains, a human-borne PRV strain (isolated from a patient, who returned to Japan from Bali, Indonesia in 2007) and a bat-borne PRV (isolated from a bat [Eonycteris spelaea] in the Philippines in 2013) were investigated in BALB/c mice using virological, pathological, and immunological study methods. RESULTS: The intranasal inoculation of BALB/c mice with human-borne PRV caused respiratory infection. In addition, all mice with immunity induced by pre-inoculation with a non-lethal dose of PRV were completely protected against lethal PRV infection. Mice treated with antiserum with neutralizing antibody activity after inoculation with a lethal dose of PRV showed a reduced fatality rate. In this mouse model, bat-borne PRV caused respiratory infection similar to human-borne PRV. PRV caused lethal respiratory disease in an animal model of PRV infection, in which BALB/c mice were used. CONCLUSIONS: The BALB/c mouse model might help to accelerate research on the virulence of PRV and be useful for evaluating the efficacy of therapeutic agents and vaccines for the treatment and prevention of PRV infection. PRV was shown for the first time to be a causative virus of respiratory disease on the basis of Koch’s postulations by the additional demonstration that PRV caused respiratory disease in mice through their intranasal inoculation with PRV.
has issue date	2017-12-14(xsd:dateTime)
bibo:doi	10.1371/journal.pntd.0006076
bibo:pmid	29240753
has license	cc-by
sha1sum (hex)	dc502e4494d5ef1e5a2f54b5df88e7c391d9a763
schema:url	https://doi.org/10.1371/journal.pntd.0006076
resource representing a document's title	Virulence, pathology, and pathogenesis of Pteropine orthoreovirus (PRV) in BALB/c mice: Development of an animal infection model for PRV
has PubMed Central identifier	PMC5730109
has PubMed identifier	29240753
schema:publication	PLoS Negl Trop Dis
resource representing a document's body	covid:dc502e4494d5ef1e5a2f54b5df88e7c391d9a763#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/dc502e4494d5ef1e5a2f54b5df88e7c391d9a763
is schema:about of	named entity 'humans' named entity 'Orthoreovirus' named entity 'Southeast Asia' named entity 'clinical' named entity 'pathology' covid:arg/dc502e4494d5ef1e5a2f54b5df88e7c391d9a763 named entity 'Serum' named entity 'intranasally' named entity 'acute phase' named entity 'PRV' named entity 'alveoli' named entity 'pulmonary infection' named entity 'goblet cells' named entity 'streptomycin' named entity 'Philippines' named entity 'weight loss' named entity 'orthoreovirus' named entity 'real-time RT-PCR' named entity 'isoflurane' named entity 'intranasally' named entity 'DMEM' named entity 'Philippines' named entity 'nasal cavity' named entity 'Pteropus poliocephalus' named entity 'Hong Kong' named entity 'spleen' named entity 'qRT-PCR' named entity 'antigen' named entity 'clinical signs' named entity 'infection' named entity 'viral antigens' named entity 'alveoli' named entity 'qRT-PCR' named entity 'alveolar duct' named entity 'supernatant' named entity 'epithelium' named entity 'RNA' named entity 'acute phase' named entity 'survival rates' named entity 'amino acid' named entity 'pathogenesis' named entity 'animal model' named entity 'IHC' named entity 'bronchiole' named entity 'Australia' named entity 'animal studies' named entity 'vaccines' named entity 'BALB/c' named entity 'nasal cavity' named entity 'viral antigens' named entity 'necrosis' named entity 'titer' named entity 'reverse transcription' named entity 'virus' named entity 'vomiting' named entity 'epithelium' named entity 'SARS' named entity 'cross-reactivity' named entity 'Genomics' named entity 'staining' named entity 'antibody' named entity 'intranasal' named entity 'H&E' named entity 'supernatant' named entity 'epithelial cells' named entity 'inflammation' named entity 'capsid protein' named entity 'blood samples' named entity 'protein' named entity 'antibody'

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