About: Topical povidone iodine inhibits bacterial growth in the oral cavity of patients on mechanical ventilation: a randomized controlled study

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About: Topical povidone iodine inhibits bacterial growth in the oral cavity of patients on mechanical ventilation: a randomized controlled study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Topical povidone iodine inhibits bacterial growth in the oral cavity of patients on mechanical ventilation: a randomized controlled study
Creator	Funahara, Madoka Hayashida, Saki Soutome, Sakiko Tsuda, Shoma Umeda, Masahiro Yanamoto, Souichi
Source	PMC
abstract	BACKGROUND: Topical 0.12% chlorhexidine has been used widely to prevent ventilator-associated pneumonia in patients undergoing mechanical ventilation. However, it is not approved for mucosal application in Japan. The aims of this study were to investigate if topical povidone iodine (i) inhibits bacterial growth and (ii) disrupts the balance of the oral microbiota. METHODS: This randomized controlled clinical trial included 23 patients who underwent mechanical ventilation in the intensive care unit. The patients were divided randomly into two groups: the intervention group (n = 16) and the control group (n = 7). All patients received oral cleaning with 3% hydrogen peroxide, followed by irrigation with tap water. The patients in the intervention group received 10% povidone iodine applied topically to the oral cavity. The concentration of total bacteria in the oropharyngeal fluid were determined before, immediately after, 1 h, 2 h, and 3 h after oral care using the Rapid Oral Bacteria Quantification System, which is based on dielectrophoresis and impedance measurements. The number of streptococci, methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa, Porphyromonas gingivalis, and Candida albicans before, immediately after, 1 h, and 3 h after oral care were estimated based on real-time polymerase chain reaction data. RESULTS: After irrigation of the oral cavity, the number of bacteria decreased, but increased again at 1 h after oral care in the control group; however, in the intervention group, the concentration of bacteria was significantly lower than that in the control group at 1 hour (p = 0.009), 2 h (p = 0.001), and 3 h (p = 0.001) after oral care. The growth of all bacterial species tested was inhibited in the intervention group at 3 h after oral care, suggesting that povidone iodine did not disturb the balance of the oral microbiota. CONCLUSIONS: Topical application of povidone iodine after cleaning and irrigation of the oral cavity inhibited bacterial growth in the oropharyngeal fluid of patients on mechanical ventilation while not disrupting the balance of the oral microbiota. TRIAL REGISTRATION: University Hospitals Medical Information Network Clinical Trials Registry (UMIN-CTR), UMIN000028307. Registered 1 September 2017.
has issue date	2020-02-24(xsd:dateTime)
bibo:doi	10.1186/s12903-020-1043-7
bibo:pmid	32093667
has license	cc-by
sha1sum (hex)	dbf69c406745076316f5b2c8a5e8c4035462d497
schema:url	https://doi.org/10.1186/s12903-020-1043-7
resource representing a document's title	Topical povidone iodine inhibits bacterial growth in the oral cavity of patients on mechanical ventilation: a randomized controlled study
has PubMed Central identifier	PMC7041202
has PubMed identifier	32093667
schema:publication	BMC Oral Health
resource representing a document's body	covid:dbf69c406745076316f5b2c8a5e8c4035462d497#body_text
is schema:about of	named entity 'impedance' named entity 'species' named entity 'fluid' named entity 'Candida' named entity 'application' named entity 'Topical' named entity 'BACKGROUND' named entity 'MECHANICAL VENTILATION' named entity 'METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS' named entity 'PORPHYROMONAS GINGIVALIS' named entity 'RAPID' named entity 'OROPHARYNGEAL' named entity '0.001' named entity 'ORAL BACTERIA' named entity 'INCREASED' named entity 'TOTAL' named entity 'DECREASED' named entity 'mucosal' named entity 'randomized' named entity 'oral' named entity 'Japan' named entity 'inhibited' named entity 'irrigation' named entity 'After' named entity 'investigate' named entity 'divided' named entity 'oral care' named entity 'ventilator-associated pneumonia' named entity 'control group' named entity 'real-time polymerase chain reaction' named entity 'bacteria' named entity 'oropharyngeal' named entity 'hydrogen peroxide' named entity 'povidone iodine' named entity 'applied topically' named entity 'mechanical ventilation' named entity 'inhibits' named entity 'disinfecting' named entity 'povidone iodine' named entity 'Japan' named entity 'risk factors' named entity 'dental plaque' named entity 'colistin' named entity 'bacteria' named entity 'microbiota' named entity 'povidone iodine' named entity 'oral care' named entity 'sample size' named entity 'povidone iodine' named entity 'VAP' named entity 'oral care' named entity 'oral cavity' named entity 'topical application' named entity 'deionized water' named entity 'oropharyngeal' named entity 'randomized controlled study' named entity 'VAP' named entity 'P. gingivalis' named entity 'Ventilator-associated pneumonia' named entity 'biostatistical' named entity 'oropharyngeal' named entity 'oral care' named entity 'microbiota' named entity 'povidone iodine' named entity 'fungi' named entity 'bacteria' named entity 'microorganism' named entity 'oral care' named entity 'oral care' named entity 'VAP' named entity 'VAP' named entity 'oropharyngeal' named entity 'bacteria' named entity 'oral mucosa' named entity 'prophylaxis' named entity 'mechanical ventilation'

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