About: Porcine IFITM1 is a host restriction factor that inhibits pseudorabies virus infection

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About: Porcine IFITM1 is a host restriction factor that inhibits pseudorabies virus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Porcine IFITM1 is a host restriction factor that inhibits pseudorabies virus infection
Creator	Wang, Qi Wang, Chun-Feng Yang, Guo-Yu Chu, Bei-Bei Li, Guo-Li Ming, Sheng-Li Su, Bing-Qian Wang, Jiang Wang, Meng-Di Zeng, Lei
Source	Elsevier; Medline; PMC
abstract	Abstract Interferon-inducible transmembrane proteins (IFITMs) restrict infection by several viruses, such as influenza A virus, West Nile virus and dengue virus. It has not been determined whether porcine IFITMs (pIFITMs) inhibit infection by pseudorabies virus (PRV), an enveloped, double-stranded DNA virus, which is the etiological agent of Aujeszky’s disease in pigs. Here, we report that PRV infection elicited pIFITM1 expression in PK15 porcine kidney epithelial cells and 3D4/21 alveolar macrophages. pIFITM2 and pIFITM3 expression was only elevated in PK15 cells during PRV infection. Depletion of pIFITM1 using RNA interference, either in PK15 or in 3D4/21 cells, enhanced PRV infection while overexpression of pIFITM1 had the opposite effect. Knockdown of pIFITM2 and pIFITM3 did not influence PRV infection, suggesting that pIFITM2 and pIFITM3 are independent of PRV infection. PRV-induced pIFITM1 expression was dependent on the cGAS/STING/TBK1/IRF3 innate immune pathway and interferon-alpha receptor-1, suggesting that pIFITM1 is up-regulated by the type I interferon signaling pathway. The anti-PRV role of pIFITM1 was inhibited upon PRV entry. Our data demonstrate that pIFITM1 is a host restriction factor that inhibits PRV entry that may shed light on a strategy for prevention of PRV infection.
has issue date	2019-11-16(xsd:dateTime)
bibo:doi	10.1016/j.ijbiomac.2019.10.162
bibo:pmid	31743714
has license	els-covid
sha1sum (hex)	dbf2805a5a92d2ba97e9fe99918ecd0f871ac286
schema:url	https://doi.org/10.1016/j.ijbiomac.2019.10.162
resource representing a document's title	Porcine IFITM1 is a host restriction factor that inhibits pseudorabies virus infection
has PubMed Central identifier	PMC7102536
has PubMed identifier	31743714
schema:publication	Int J Biol Macromol
resource representing a document's body	covid:dbf2805a5a92d2ba97e9fe99918ecd0f871ac286#body_text
is schema:about of	named entity 'RNA interference' named entity 'IRF3' named entity 'Viral' named entity 'up-regulated' named entity 'PRV' named entity 'cells' named entity 'licenses' named entity 'inhibits' named entity 'IFITM1' named entity 'FACTOR' named entity 'HOST' named entity 'RNA INTERFERENCE' named entity 'PORCINE' named entity 'INFLUENCE' named entity 'HOST' named entity 'EFFECT' named entity 'EPITHELIAL CELLS' named entity 'PIGS' named entity 'INTERFERON-ALPHA RECEPTOR' named entity 'EXPRESSION' named entity 'PREVENTION OF' named entity 'CELLS' named entity 'VIRAL ENTRY' named entity '27S' named entity 'PSEUDORABIES VIRUS' named entity 'LICENSE' named entity 'VIRUS INFECTION' named entity 'DID' named entity 'FACTOR' named entity 'PATHWAY' named entity 'REPORT' named entity 'OUR' named entity 'PORCINE' named entity 'RESTRICTION' named entity 'ORG' named entity 'IS A' named entity 'ELICITED' named entity 'CGAS' named entity 'DETERMINED' named entity 'INTERFERON' named entity 'VIRUSES' named entity 'HERE' named entity 'DEPLETION' named entity 'INDUCIBLE' named entity 'USING' named entity 'ELEVATED' named entity 'NC-' named entity 'RESTRICTION' named entity 'IMMUNE' named entity 'ENTRY' named entity 'OVEREXPRESSION' named entity 'GAS' named entity 'PSEUDORABIES VIRUS' named entity 'DENGUE VIRUS' named entity 'TYPE I INTERFERON SIGNALING PATHWAY' named entity 'DISEASE' named entity 'DEPENDENT' named entity 'KEYWORDS' named entity 'INDEPENDENT OF' named entity 'INFLUENZA A VIRUS' named entity 'IS A' named entity '3D4' named entity 'DATA' named entity 'ENHANCED' named entity 'AGENT' named entity 'STRATEGY' named entity 'KIDNEY' named entity 'PK15' named entity 'TRANSMEMBRANE PROTEINS' named entity 'ALVEOLAR MACROPHAGES' named entity 'INFECTION' named entity 'EITHER'

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