About: Autophagy sustains the replication of porcine reproductive and respiratory virus in host cells

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Autophagy sustains the replication of porcine reproductive and respiratory virus in host cells
Creator	Zhou, Lei Ge, Xinna Guo, Xin Yang, Hanchun Hu, Hongbo Kou, Qiuwen Liu, Qinghao Qin, Yixian
Source	Elsevier; Medline; PMC
abstract	In this study, we confirmed the autophagy induced by porcine reproductive and respiratory syndrome virus (PRRSV) in permissive cells and investigated the role of autophagy in the replication of PRRSV. We first demonstrated that PRRSV infection significantly results in the increased double-membrane vesicles, the accumulation of LC3 fluorescence puncta, and the raised ratio of LC3-II/β-actin, in MARC-145 cells. Then we discovered that induction of autophagy by rapamycin significantly enhances the viral titers of PRRSV, while inhibition of autophagy by 3-MA and silencing of LC3 gene by siRNA reduces the yield of PRRSV. The results showed functional autolysosomes can be formed after PRRSV infection and the autophagosome–lysosome-fusion inhibitor decreases the virus titers. We also examined the induction of autophagy by PRRSV infection in pulmonary alveolar macrophages. These findings indicate that autophagy induced by PRRSV infection plays a role in sustaining the replication of PRRSV in host cells.
has issue date	2012-08-01(xsd:dateTime)
bibo:doi	10.1016/j.virol.2012.03.022
bibo:pmid	22564420
has license	no-cc
sha1sum (hex)	dbecbcff9512f58e244a9bba62b374408a775907
schema:url	https://doi.org/10.1016/j.virol.2012.03.022
resource representing a document's title	Autophagy sustains the replication of porcine reproductive and respiratory virus in host cells
has PubMed Central identifier	PMC7111961
has PubMed identifier	22564420
schema:publication	Virology
resource representing a document's body	covid:dbecbcff9512f58e244a9bba62b374408a775907#body_text
is schema:about of	named entity 'REPLICATION' named entity 'reproductive' named entity 'vesicles' named entity 'titers' named entity 'autophagy' named entity 'autophagy' named entity 'respiratory' named entity 'porcine' named entity 'INDUCED' named entity 'MARC' named entity 'SILENCING' named entity 'CONFIRMED' named entity 'FORMED' named entity 'ACCUMULATION' named entity 'STUDY' named entity 'LC3' named entity 'SIRNA' named entity 'FUNCTIONAL' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'DEMONSTRATED' named entity 'FLUORESCENCE' named entity 'INVESTIGATED' named entity 'FUSION INHIBITOR' named entity 'EXAMINED' named entity 'VESICLES' named entity 'THESE' named entity 'DOUBLE' named entity 'HOST CELLS' named entity 'PORCINE' named entity 'HOST CELLS' named entity 'AUTOPHAGY' named entity 'VIRUS' named entity 'LC3-II' named entity 'RAPAMYCIN' named entity 'VIRAL' named entity 'MEMBRANE' named entity 'CELLS' named entity 'INDUCTION' named entity 'AUTOPHAGOSOME' named entity 'RATIO' named entity 'YIELD' named entity 'REPRODUCTIVE' named entity 'RESPIRATORY VIRUS' named entity 'ROLE' named entity 'GENE' named entity 'ACTIN' named entity 'RESULTS' named entity 'SUSTAINING' named entity 'AUTOPHAGY' named entity 'PULMONARY' named entity 'LYSOSOME' named entity 'DECREASES' named entity 'INCREASED' named entity 'INFECTION' named entity 'RAISED' named entity '2FB' named entity 'REPLICATION' named entity 'INHIBITION' named entity 'FINDINGS' named entity '145' named entity 'PLAYS' named entity 'ALVEOLAR MACROPHAGES' covid:arg/dbecbcff9512f58e244a9bba62b374408a775907 named entity 'confirmed' named entity 'respiratory' named entity 'alveolar' named entity 'LC3' named entity 'induction' named entity 'virus' named entity 'ratio' named entity 'replication' named entity 'autophagy' named entity 'infection' named entity 'fusion inhibitor'

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