About: Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies

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About: Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies
Creator	Bjorkman, Pamela Nussenzweig, Michel West, Anthony Bieniasz, Paul Barnes, Christopher Caskey, Marina Finkin, Shlomo Gaebler, Christian Gristick, Harry Hagglof, Thomas Hatziioannou, Theodora Hoffman, Pauline Hoffmann, Magnus Huey-Tubman, Kathryn Hurley, Arlene Koranda, Nicholas Lorenzi, Julio Millard, Katrina Muecksch, Frauke Robbiani, Davide Schmidt, Fabian Sharaf, Naima Weisblum, Yiska
topic	covid:dbad412eac3b4c3e0cf96339e95425e37cc9d6ef#this
Source	BioRxiv; Medline; PMC
abstract	Neutralizing antibody responses to coronaviruses focus on the trimeric spike, with most against the receptor-binding domain (RBD). Here we characterized polyclonal IgGs and Fabs from COVID-19 convalescent individuals for recognition of coronavirus spikes. Plasma IgGs differed in their degree of focus on RBD epitopes, recognition of SARS-CoV, MERS-CoV, and mild coronaviruses, and how avidity effects contributed to increased binding/neutralization of IgGs over Fabs. Electron microscopy reconstructions of polyclonal plasma Fab-spike complexes showed recognition of both S1(A) and RBD epitopes. A 3.4Å cryo-EM structure of a neutralizing monoclonal Fab-S complex revealed an epitope that blocks ACE2 receptor-binding on “up” RBDs. Modeling suggested that IgGs targeting these sites have different potentials for inter-spike crosslinking on viruses and would not be greatly affected by identified SARS-CoV-2 spike mutations. These studies structurally define a recurrent anti-SARS-CoV-2 antibody class derived from VH3–53/VH3–66 and similarity to a SARS-CoV VH3–30 antibody, providing criteria for evaluating vaccine-elicited antibodies.
has issue date	2020-05-29(xsd:dateTime)
bibo:doi	10.1101/2020.05.28.121533
bibo:pmid	32577645
has license	cc-by-nc-nd
sha1sum (hex)	dbad412eac3b4c3e0cf96339e95425e37cc9d6ef
schema:url	https://doi.org/10.1101/2020.05.28.121533
resource representing a document's title	Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies
has PubMed Central identifier	PMC7302198
has PubMed identifier	32577645
schema:publication	bioRxiv
resource representing a document's body	covid:dbad412eac3b4c3e0cf96339e95425e37cc9d6ef#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/dbad412eac3b4c3e0cf96339e95425e37cc9d6ef
is schema:about of	named entity 'SARS-CoV-2' named entity 'focus' named entity 'responses' named entity 'evaluating' named entity 'avidity' named entity 'antibodies' named entity 'Electron microscopy' named entity 'neutralizing' named entity 'trimeric' named entity 'RBD' named entity 'SARS-CoV' named entity 'epitope' named entity 'spike' named entity 'RBD' named entity 'complexes' named entity 'reconstructions' named entity 'antibodies' named entity 'epitopes' named entity 'SARS-CoV' named entity 'viruses' named entity 'COVID' named entity 'RBD' named entity 'receptor' named entity 'coronaviruses' named entity 'cryo-EM' named entity 'antibody' named entity 'Electron microscopy' named entity 'SARS-CoV-2' named entity 'antibodies' named entity 'epitopes' named entity 'coronaviruses' named entity 'human coronaviruses' named entity 'MERS-CoV' named entity 'SARS-CoV-2' named entity 'EC50' named entity 'viral titers' named entity 'coronavirus' named entity 'genomes' named entity 'epitope' named entity 'SARS-CoV-2' named entity 'murine leukemia virus' named entity 'SARS-CoV-2' named entity 'mAb' named entity 'IgG' named entity 'RBD' named entity 'antigen' named entity 'RBDs' named entity 'heavy chain' named entity 'epitope' named entity 'vaccination' named entity 'SARS-CoV-2' named entity 'transfection' named entity 'structural studies' named entity '3D reconstruction' named entity 'epitopes' named entity 'PDB' named entity 'receptor'

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