About: Analysis of adjunctive serological detection to nucleic acid test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosis

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About: Analysis of adjunctive serological detection to nucleic acid test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Analysis of adjunctive serological detection to nucleic acid test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosis
Creator	Li, Yuan Liu, Fang Liu, Rui Li, Fang Luo, Zhen Wu, Kailang Wu, Zhen Zhu, Chengliang Li, Dong Yuan, L Han, Huan Liu, R Han, Li, D Liu, X Wu, K Yuan, Li Zhu, Zhu, C Liu, F Shereen, M Shereen, Muhammad Han, H Liu, Kailang Liu, Xinghui Luo, Chengliang Luo, Z Muhammad, Adnan Niu, Dong Niu, Z Niu, Zhili Shereen, Jiesheng Zhen, J Zhen, Jiesheng Zhen, Zhili
source	Elsevier; Medline; PMC
abstract	BACKGROUND: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused coronavirus disease 2019 (COVID-19) epidemic in China, December 2019. The clinical features and treatment of COVID-19 patients remain largely elusive. However, accurate detection is required for SARS-CoV-2 infection diagnosis. We aimed to evaluate the antibodies-based test and nucleic acid-based test for SARS-CoV-2-infected patients. METHODS: We retrospectively studied 133 patients diagnosed with SARS-CoV-2 and admitted to Renmin Hospital of Wuhan University, China, from January 23 to March 1, 2020. Demographic data, clinical records, laboratory tests, and outcomes were collected. Data were accessed by SARS-CoV-2 IgM-IgG antibody test and real-time reverse transcriptase PCR (RT-PCR) detection for SARS-CoV-2 nucleic acid in COVID-19 patients. RESULTS: Of 133 COVID-19 patients, there were 44 moderate cases, 52 severe cases, and 37 critical cases with no differences in gender and age among three subgroups. In RT-PCR detection, the positive rate was 65.9%, 71.2%, and 67.6% in moderate, severe, and critical cases, respectively. Whereas the positive rate of IgM/IgG antibody detection in patients was 79.5%/93.2%, 82.7%/100%, and 73.0%/97.3% in moderate, severe, and critical cases, respectively. Moreover, the IgM and IgG antibodies concentrations were also examined with no differences among three subgroups. CONCLUSION: The IgM-IgG antibody test exhibited a useful adjunct to RT-PCR detection, and improved the accuracy in COVID-19 diagnosis regardless of the severity of illness, which provides an effective complement to the false-negative results from a nucleic acid test for SARS-CoV-2 infection diagnosis after onsets.
has issue date	2020-06-26(xsd:dateTime)
bibo:doi	10.1016/j.intimp.2020.106746
bibo:pmid	32619956
has license	no-cc
sha1sum (hex)	db98b3c9c81eeed7359784a746c7da7ec35bc632
schema:url	https://doi.org/10.1016/j.intimp.2020.106746
resource representing a document's title	Analysis of adjunctive serological detection to nucleic acid test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosis
has PubMed Central identifier	PMC7318959
has PubMed identifier	32619956
schema:publication	Int Immunopharmacol
resource representing a document's body	covid:db98b3c9c81eeed7359784a746c7da7ec35bc632#body_text
is schema:about of	named entity 'infection' named entity 'infected' named entity 'patients' named entity 'Nucleic Acid' named entity 'Infection' named entity 'ACCURATE' named entity 'DETECTION' named entity 'BASED' named entity 'caused' named entity 'SARS-CoV-2' named entity 'headache' named entity 'IgM' named entity 'antibodies' named entity 'SARS-CoV-2' named entity 'patients' named entity 'remain' named entity 'China' named entity 'coronavirus disease 2019' named entity 'diagnosis' named entity 'Diag' named entity 'Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)' named entity 'antibodies' named entity 'clinical features' named entity 'COVID' named entity 'SARS-CoV-2' named entity 'Severe Acute Respiratory Syndrome Coronavirus 2' named entity 'Serological' named entity 'SARS-CoV-2' named entity 'Severe Acute Respiratory Syndrome Coronavirus 2' named entity 'epidemiology' named entity 'complement' named entity 'SARS-CoV-2' named entity 'pathogen' named entity 'COVID' named entity 'SARS-CoV-2' named entity 'moderate cases' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'RT-PCR test' named entity 'SARS-CoV-2' named entity 'IgM' named entity 'infection' named entity 'RT-PCR' named entity 'significant difference' named entity 'IgG antibody' named entity 'antibody' named entity 'severe acute respiratory syndrome coronavirus 2'

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