About: Characterization of protein–protein interactions between the nucleocapsid protein and membrane protein of the SARS coronavirus

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About: Characterization of protein–protein interactions between the nucleocapsid protein and membrane protein of the SARS coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization of protein–protein interactions between the nucleocapsid protein and membrane protein of the SARS coronavirus
Creator	Andonov, Anton Feldmann, Heinz Li, Yan Li, Xuguang Cao, Jingxin He, Runtao Bastien, Nathalie Cutts, Todd Plummer, Frank Baker, Lindsay Ballantine, Melissa Dobie, Frederick Leeson, Andrew Strocher, Ute Theriault, Steven Tyler, Shaun Booth, Timothy
Source	Elsevier; Medline; PMC
abstract	Abstract The human coronavirus, associated with severe acute respiratory syndrome (SARS-CoV), was identified and molecularly characterized in 2003. Sequence analysis of the virus indicates that there is only 20% amino acid (aa) identity with known coronaviruses. Previous studies indicate that protein–protein interactions amongst various coronavirus proteins are critical for viral assembly. Yet, little sequence homology between the newly identified SARS-CoV and those previously studied coronaviruses suggests that determination of protein–protein interaction and identification of amino acid sequences, responsible for such interaction in SARS-CoV, are necessary for the elucidation of the molecular mechanism of SARS-CoV replication and rationalization of anti-SARS therapeutic intervention. In this study, we employed mammalian two-hybrid system to investigate possible interactions between SARS-CoV nucleocapsid (N) and the membrane (M) proteins. We found that interaction of the N and M proteins takes place in vivo and identified that a stretch of amino acids (168–208) in the N protein may be critical for such protein–protein interactions. Importantly, the same region has been found to be required for multimerization of the N protein (He et al., 2004) suggesting this region may be crucial in maintaining correct conformation of the N protein for self-interaction and interaction with the M protein.
has issue date	2004-10-31(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2004.05.002
bibo:pmid	15351485
has license	els-covid
sha1sum (hex)	db7472330d9764a64e2b367d4395504f2e4875aa
schema:url	https://doi.org/10.1016/j.virusres.2004.05.002
resource representing a document's title	Characterization of protein–protein interactions between the nucleocapsid protein and membrane protein of the SARS coronavirus
has PubMed Central identifier	PMC7127797
has PubMed identifier	15351485
schema:publication	Virus Research
resource representing a document's body	covid:db7472330d9764a64e2b367d4395504f2e4875aa#body_text
is schema:about of	named entity 'MEMBRANE PROTEIN' named entity '2003' named entity 'self-interaction' named entity 'protein-protein interaction' named entity 'CHARACTERIZATION' named entity 'STUDY' named entity 'STUDIES' named entity 'INTERACTIONS' named entity 'POSSIBLE' named entity 'AMINO ACID SEQUENCES' named entity 'STRETCH' named entity 'CORONAVIRUS' named entity 'IDENTIFICATION' named entity 'PROTEIN ' named entity 'CRITICAL' named entity 'CHARACTERIZED' named entity 'SEQUENCE HOMOLOGY' named entity 'FOUND' named entity 'NECESSARY' named entity 'VIRAL ASSEMBLY' named entity 'PROTEIN-PROTEIN INTERACTION' named entity 'SEQUENCE ANALYSIS' named entity 'PREVIOUS' named entity 'NEWLY' named entity 'MOLECULAR MECHANISM' named entity 'EMPLOYED' named entity 'VIRUS' named entity 'REPLICATION' named entity 'PLACE' named entity 'INTERACTION' named entity 'RESPONSIBLE' named entity 'VARIOUS' named entity 'MEMBRANE' named entity '20%' named entity 'N PROTEIN' named entity 'TO INVESTIGATE' named entity 'HUMAN CORONAVIRUS' named entity 'LITTLE' named entity 'AMINO ACIDS' named entity 'DETERMINATION' named entity 'CONFORMATION' named entity 'IDENTITY' named entity 'MAINTAINING' named entity 'NUCLEOCAPSID PROTEIN' named entity 'PROTEINS' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'PROTEIN-PROTEIN INTERACTIONS' named entity 'SARS CORONAVIRUS' named entity 'TWO-HYBRID' named entity 'KNOWN' named entity 'SYSTEM' named entity 'CORRECT' named entity 'PROTEIN-PROTEIN INTERACTIONS' named entity 'SARS' named entity 'CORONAVIRUSES' named entity 'IN VIVO' named entity 'PROTEIN ' named entity 'REQUIRED' named entity 'SELF' named entity 'M PROTEINS' named entity 'AMINO ACID' named entity 'MAMMALIAN' named entity 'RATIONALIZATION' named entity 'NUCLEOCAPSID' named entity 'REGION'

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