About: CT in relation to RT-PCR in diagnosing COVID-19 in the Netherlands: a prospective study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CT in relation to RT-PCR in diagnosing COVID-19 in the Netherlands: a prospective study
Creator	Gietema, Hester Martijn Nobel, J Nelissen, Irene Van Alphen, Lieke Wildberger, Joachim Lambriks, Lars Lashof, Oude Ml, Astrid Stassen, Patricia Zelis, Noortje
Source	MedRxiv
abstract	Introduction Early differentiation between emergency department (ED) patients with and without corona virus disease (COVID-19) is very important. Chest CT scan may be helpful in early diagnosing of COVID-19. We investigated the diagnostic accuracy of CT using RT-PCR for SARS-CoV-2 as reference standard and investigated reasons for discordant results between the two tests. Methods In this prospective single centre study in the Netherlands, all adult symptomatic ED patients had both a CT scan and a PCR upon arrival at the ED. CT results were compared with PCR test(s). Diagnostic accuracy was calculated. Discordant results were investigated using discharge diagnoses. Results Between March 13th and March 24th 2020, 193 symptomatic ED patients were included. In total, 43.0% of patients had a positive PCR and 56.5% a positive CT, resulting in a sensitivity of 89.2%, specificity 68.2%, likelihoodratio (LR) + 2.81 and LR- 0.16. Sensitivity was higher in patients with high risk pneumonia (CURB-65 score ≥3; n=17, 100%) and with sepsis (SOFA score ≥2; n=137, 95.5%). Of the 35 patients (31.8%) with a suspicious CT and a negative PCR, 9 had another respiratory viral pathogen, and in 7 patients, COVID-19 was considered likely. One of nine patients with a non-suspicious CT and a positive PCR had developed symptoms within 48 hours before scanning. Discussion The accuracy of chest CT in symptomatic ED patients is high, but used as a single diagnostic test, CT can not safely diagnose or exclude COVID-19. However, CT can be used as a quick first screening tool.
has issue date	2020-04-24(xsd:dateTime)
bibo:doi	10.1101/2020.04.22.20070441
has license	medrxiv
sha1sum (hex)	db1d021803af3ab8ad6ea7d6043c551ae04dfe74
schema:url	https://doi.org/10.1101/2020.04.22.20070441
resource representing a document's title	CT in relation to RT-PCR in diagnosing COVID-19 in the Netherlands: a prospective study
resource representing a document's body	covid:db1d021803af3ab8ad6ea7d6043c551ae04dfe74#body_text
is schema:about of	named entity 'RT-PCR' named entity 'USING' named entity 'MAY BE' named entity 'EMERGENCY DEPARTMENT' named entity 'reference' named entity 'COVID-19' named entity 'patients' named entity 'COVID' named entity 'RT-PCR' named entity 'chest CT' named entity 'virus' named entity 'COVID' named entity 'chest CT' named entity 'pleural effusion' named entity 'COVID' named entity 'COVID-19' named entity 'crazy paving' named entity 'gene' named entity 'respiratory syncytial virus' named entity 'PCR' named entity 'COVID' named entity 'viral pathogens' named entity 'SARS-CoV-2' named entity 'COVID-19' named entity 'COVID' named entity 'detection limit' named entity 'CT scans' named entity 'RT-PCR' named entity 'preprint' named entity 'RT-PCR' named entity 'prospective study' named entity 'Rhinovirus' named entity 'chest CT' named entity 'diagnostic accuracy' named entity 'medRxiv' named entity 'diagnostic accuracy' named entity 'SOFA score' named entity 'chest CT' named entity 'METC' named entity 'COVID' named entity 'COVID-19' named entity 'COVID-19' named entity 'COVID' named entity 'medRxiv' named entity 'CT scan' named entity 'sore throat' named entity 'preprint' named entity 'pneumonia' named entity 'COVID' named entity 'CT scanning' named entity 'CT scans' named entity 'CURB-65 score' named entity 'emergency department' named entity 'preprint' named entity 'preprint' named entity 'false negative' named entity 'COVID' named entity 'PCR' named entity 'SOFA score' named entity 'PCR' named entity 'thorax' named entity 'CT scan' named entity 'sepsis' named entity 'intubated' named entity 'pneumonia' named entity 'preprint' named entity 'RdrP' named entity 'PCR test' named entity 'CT scanning' named entity 'COVID-19' named entity 'CTs' named entity 'PCR' named entity 'RT-PCR' named entity 'peer review' named entity 'Cardiovascular' named entity 'COVID-19'

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