About: Management of Antimicrobial Agents in Abdominal Organ Transplant Patients in Intensive Care Unit

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Management of Antimicrobial Agents in Abdominal Organ Transplant Patients in Intensive Care Unit
Creator	Axelrod, David Ince, Dilek Kaviani, Aaron
Source	PMC
abstract	PURPOSE OF REVIEW: Early diagnosis of infections and immediate initiation of appropriate antimicrobials are crucial in the management of patients before and after organ transplantation. We reviewed the most recent literature and guidelines in this field and organized the current recommendations for healthcare professionals caring for critically ill organ transplant recipients. RECENT FINDINGS: The incidence of multidrug-resistant organisms is increasing. Multidrug-resistant Gram-negative bacteria comprise about 14% of organisms. Vancomycin-resistant enterococci bloodstream infections are also on the rise, as 20.5% of nosocomial enterococci are now vancomycin-resistant, changing empiric antibiotic selection. Fluconazole-resistant Candida species comprise up to 46% of cases of candidemia in hospitalized patients. Consequently, new guidelines recommend primary use of echinocandins in patients with candidemia who have moderate-to-severe disease. Finally, the incidence of emergence of ganciclovir-resistant cytomegalovirus infection in patients is 5–12%, requiring early recognition and change to alternative regimens in the case of poor response to therapy. SUMMARY: Bloodstream infections are a major cause of mortality and morbidity in solid organ transplantation. Mortality as high as 24% and 50% have been reported with sepsis and septic shock respectively. As such, bloodstream infections should be diagnosed rapidly and intravenous antibiotics should be started immediately. Appropriate resuscitation should be initiated and the number and/or dose of immunosuppressive drugs should be reduced. Proper source control must also be achieved with radiologic drainage or surgical intervention as appropriate. Initial antibiotic treatment of these patients should cover both Gram-positive organisms, especially in the presence of intravascular catheters, and Gram-negative bacteria. Echinocandins like caspofungin should also be considered especially in critically ill patients, particularly if a patient has been on total parenteral nutrition or broad-spectrum antibiotics.
has issue date	2020-01-24(xsd:dateTime)
bibo:doi	10.1007/s40472-020-00268-0
has license	no-cc
sha1sum (hex)	db1ad0cf0c373393f7dab12fc2743b12a0a1431e
schema:url	https://doi.org/10.1007/s40472-020-00268-0
resource representing a document's title	Management of Antimicrobial Agents in Abdominal Organ Transplant Patients in Intensive Care Unit
has PubMed Central identifier	PMC7222087
schema:publication	Curr Transplant Rep
resource representing a document's body	covid:db1ad0cf0c373393f7dab12fc2743b12a0a1431e#body_text
is schema:about of	named entity 'radiologic' named entity 'organ transplantation' named entity 'Bloodstream' named entity 'catheters' named entity 'organ transplantation' named entity 'candidemia' named entity 'resuscitation' named entity 'presence' named entity 'AND' named entity 'Intensive Care Unit' named entity 'Management' named entity 'SEVERE DISEASE' named entity 'INTRAVASCULAR' named entity 'PATIENTS' named entity 'CANDIDA SPECIES' covid:arg/db1ad0cf0c373393f7dab12fc2743b12a0a1431e named entity 'species' named entity 'source control' named entity 'initiation' named entity 'Gram-negative bacteria' named entity 'changing' named entity 'caspofungin' named entity 'sepsis' named entity 'literature' named entity 'drainage' named entity 'alternative' named entity 'caring' named entity 'Organ Transplant' named entity 'solid organ transplantation' named entity 'Multidrug-resistant' named entity 'caspofungin' named entity 'surgical intervention' named entity 'healthcare professionals' named entity 'antimicrobials' named entity 'Fluconazole' named entity 'candidemia' named entity 'intravascular catheters' named entity 'ganciclovir' named entity 'critically ill patients' named entity 'candidemia' named entity 'organ transplantation' named entity 'Vancomycin-resistant enterococci' named entity 'intravenous antibiotics' named entity 'Organ Transplant' named entity 'Model for End-Stage Liver Disease' named entity 'viral infections' named entity 'Gram-positive bacteria' named entity 'septic shock' named entity 'pancreas transplant' named entity 'Source control' named entity 'albumin' named entity 'Prophylactic measures' named entity 'SBP' named entity 'Cystoscopic' named entity 'rapamycin' named entity 'Gram-negative bacilli' named entity 'ESLD' named entity 'sepsis' named entity 'empiric' named entity 'kidney transplant' named entity 'organ failure' named entity 'source control' named entity 'UTIs' named entity 'vancomycin' named entity 'infection' named entity 'S. aureus' named entity 'total parenteral nutrition' named entity 'Echinocandins' named entity 'SOT' named entity 'immunosuppression' named entity 'lung' named entity 'surgical intervention' named entity 'fungal infections' named entity 'renal failure' named entity 'antifungals' named entity 'supportive care' named entity 'seizures' named entity 'electroencephalography' named entity 'Candidemia' named entity 'Echinocandins' named entity 'beta-lactams'

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