About: SARS-CoV-2 neutralizing human antibodies protect against lower respiratory tract disease in a hamster model

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS-CoV-2 neutralizing human antibodies protect against lower respiratory tract disease in a hamster model
Creator	Kuiken, Thijs Koopmans, Marion Herfst, Sander Li, Wentao Wang, Chunyan Rockx, Barry Grosveld, Frank Haagmans, Bart Berend, Jan Bosch, Geurtsvankessel, Corine Okba, Nisreen Van Kuppeveld, Frank De Vries, Rory Van Run, Peter De Meulder, Dennis Bestebroer, Drabek, Lamers, Noack, Danny Rijnders, Bart Rokx, Casper
Source	BioRxiv
abstract	Effective clinical intervention strategies for COVID-19 are urgently needed. Although several clinical trials have evaluated the use of convalescent plasma containing virus-neutralizing antibodies, the effectiveness has not been proven. We show that hamsters treated with a high dose of human convalescent plasma or a monoclonal antibody were protected against weight loss showing reduced pneumonia and pulmonary virus replication compared to control animals. However, a ten-fold lower dose of convalescent plasma showed no protective effect. Thus, variable and relatively low levels of virus neutralizing antibodies in convalescent plasma may limit their use for effective antiviral therapy, favouring concentrated, purified (monoclonal) antibodies.
has issue date	2020-08-24(xsd:dateTime)
bibo:doi	10.1101/2020.08.24.264630
has license	biorxiv
sha1sum (hex)	daaca00dc450edc0960ee564c4dbcec04c96867f
schema:url	https://doi.org/10.1101/2020.08.24.264630
resource representing a document's title	SARS-CoV-2 neutralizing human antibodies protect against lower respiratory tract disease in a hamster model
schema:publication	bioRxiv
resource representing a document's body	covid:daaca00dc450edc0960ee564c4dbcec04c96867f#body_text
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