About: Circulating Levels of Tumor Necrosis Factor-Alpha Receptor 2 Are Increased in Heart Failure with Preserved Ejection Fraction Relative to Heart Failure with Reduced Ejection Fraction: Evidence for a Divergence in Pathophysiology

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Circulating Levels of Tumor Necrosis Factor-Alpha Receptor 2 Are Increased in Heart Failure with Preserved Ejection Fraction Relative to Heart Failure with Reduced Ejection Fraction: Evidence for a Divergence in Pathophysiology Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Circulating Levels of Tumor Necrosis Factor-Alpha Receptor 2 Are Increased in Heart Failure with Preserved Ejection Fraction Relative to Heart Failure with Reduced Ejection Fraction: Evidence for a Divergence in Pathophysiology
Creator	Anderson, Todd Becher, Harald Kassiri, Zamaneh Lo, Jennifer Wang, Zuocheng Putko, Brendan Oudit, Gavin Dyck, Jason
Source	PMC
abstract	BACKGROUND: Various pathways have been implicated in the pathogenesis of heart failure (HF) with preserved ejection fraction (HFPEF). Inflammation in response to comorbid conditions, such as hypertension and diabetes, may play a proportionally larger role in HFPEF as compared to HF with reduced ejection fraction (HFREF). METHODS AND RESULTS: This study investigated inflammation mediated by the tumor necrosis factor-alpha (TNFα) axis in community-based cohorts of HFPEF patients (n = 100), HFREF patients (n = 100) and healthy controls (n = 50). Enzyme-linked immunosorbent assays were used to investigate levels of TNFα, its two receptors (TNFR1 and TNFR2), and a non-TNFα cytokine, interleukin-6 (IL-6), in plasma derived from peripheral blood samples. Plasma levels of TNFα and TNFR1 were significantly elevated in HFPEF relative to controls, while levels of TNFR2 were significantly higher in HFPEF than both controls and HFREF. TNFα, TNFR1 and TNFR2 were each significantly associated with at least two of the following: age, estimated glomerular filtration rate, hypertension, diabetes, smoking, peripheral vascular disease or history of atrial fibrillation. TNFR2 levels were also significantly associated with increasing grade of diastolic dysfunction and severity of symptoms in HFPEF. CONCLUSIONS: Inflammation mediated through TNFα and its receptors, TNFR1 and TNFR2, may represent an important component of a comorbidity-induced inflammatory response that partially drives the pathophysiology of HFPEF.
has issue date	2014-06-12(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0099495
bibo:pmid	24923671
has license	cc-by
sha1sum (hex)	daa3f7d4838adebf0aac1be3cda2924fc1d2106a
schema:url	https://doi.org/10.1371/journal.pone.0099495
resource representing a document's title	Circulating Levels of Tumor Necrosis Factor-Alpha Receptor 2 Are Increased in Heart Failure with Preserved Ejection Fraction Relative to Heart Failure with Reduced Ejection Fraction: Evidence for a Divergence in Pathophysiology
has PubMed Central identifier	PMC4055721
has PubMed identifier	24923671
schema:publication	PLoS One
resource representing a document's body	covid:daa3f7d4838adebf0aac1be3cda2924fc1d2106a#body_text
is schema:about of	named entity 'VARIOUS' named entity 'RESPONSE TO' named entity 'COMPARED' named entity 'BACKGROUND' named entity 'PRESERVED' named entity 'Background' named entity 'Ejection Fraction' named entity 'Evidence' named entity 'Pathophysiology' named entity 'DIVERGENCE' covid:arg/daa3f7d4838adebf0aac1be3cda2924fc1d2106a named entity 'PLAY' named entity 'PATHWAYS' named entity 'COMORBID CONDITIONS' named entity 'REDUCED EJECTION FRACTION' named entity 'INFLAMMATION' named entity 'PATHOGENESIS' named entity 'INCREASED' named entity 'HEART FAILURE WITH PRESERVED EJECTION FRACTION' named entity 'TUMOR NECROSIS FACTOR-ALPHA RECEPTOR' named entity 'CIRCULATING' named entity 'PATHOPHYSIOLOGY' named entity 'LEVELS' named entity 'EVIDENCE FOR' named entity 'HYPERTENSION' named entity 'HEART FAILURE' named entity 'HAVE' named entity 'HEART FAILURE WITH REDUCED EJECTION FRACTION' named entity 'RELATIVE TO' named entity 'LARGER' named entity 'ROLE' named entity 'DIABETES' named entity 'EJECTION FRACTION' named entity 'Inflammation' named entity 'pathogenesis' named entity 'ejection fraction' named entity 'Heart Failure with Reduced Ejection Fraction' named entity 'Advanced age' named entity 'plasma volume' named entity 'diastolic dysfunction' named entity 'tumor' named entity 'diastolic dysfunction' named entity 'TNFa' named entity 'biomarker' named entity 'diastolic dysfunction' named entity 'HFPEF' named entity 'functional class' named entity 'TNFa' named entity 'E-64' named entity 'hypertension' named entity 'Molecular Devices' named entity 'hypertension' named entity 'plasma' named entity 'obese' named entity 'morbidity' named entity 'logarithmic scale' named entity 'cardiac hypertrophy' named entity 'substrate' named entity 'diastolic dysfunction' named entity 'ordinal logistic regression' named entity 'Diastolic dysfunction' named entity 'inflammatory markers' named entity 'threonine' named entity 'TNFa' named entity 'TNFR2' named entity 'serine protease inhibitor' named entity 'biplane' named entity 'ACEi' named entity 'pulmonary hypertension' named entity 'creatinine' named entity 'TNFR1' named entity 'wavelength' named entity 'plasma' named entity 'IL-6'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software