About: Impact of Influenza on Pneumococcal Vaccine Effectiveness during Streptococcus pneumoniae Infection in Aged Murine Lung

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About: Impact of Influenza on Pneumococcal Vaccine Effectiveness during Streptococcus pneumoniae Infection in Aged Murine Lung Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Impact of Influenza on Pneumococcal Vaccine Effectiveness during Streptococcus pneumoniae Infection in Aged Murine Lung
Creator	Yang, Jianjun Cho, Soo Harris, Rebecca Jirru, Ermias Lee, Stefi Stout-Delgado, Heather
source	Medline; PMC
abstract	Changes in innate and adaptive immune responses caused by viral imprinting can have a significant direct or indirect influence on secondary infections and vaccine responses. The purpose of our current study was to investigate the role of immune imprinting by influenza on pneumococcal vaccine effectiveness during Streptococcus pneumoniae infection in the aged murine lung. Aged adult (18 months) mice were vaccinated with the pneumococcal polyvalent vaccine Pneumovax (5 mg/mouse). Fourteen days post vaccination, mice were instilled with PBS or influenza A/PR8/34 virus (3.5 × 10(2) PFU). Control and influenza-infected mice were instilled with PBS or S. pneumoniae (1 × 10(3) CFU, ATCC 6303) on day 7 of infection and antibacterial immune responses were assessed in the lung. Our results illustrate that, in response to a primary influenza infection, there was diminished bacterial clearance and heightened production of pro-inflammatory cytokines, such as IL6 and IL1β. Vaccination with Pneumovax decreased pro-inflammatory cytokine production by modulating NFҡB expression; however, these responses were significantly diminished after influenza infection. Taken together, the data in our current study illustrate that immune imprinting by influenza diminishes pneumococcal vaccine efficacy and, thereby, may contribute to increased susceptibility of older persons to a secondary infection with S. pneumoniae.
has issue date	2020-06-11(xsd:dateTime)
bibo:doi	10.3390/vaccines8020298
bibo:pmid	32545261
has license	cc-by
sha1sum (hex)	daa31dc5918bfaa7bda92536f551de34b95158a0
schema:url	https://doi.org/10.3390/vaccines8020298
resource representing a document's title	Impact of Influenza on Pneumococcal Vaccine Effectiveness during Streptococcus pneumoniae Infection in Aged Murine Lung
has PubMed Central identifier	PMC7349919
has PubMed identifier	32545261
schema:publication	Vaccines (Basel)
resource representing a document's body	covid:daa31dc5918bfaa7bda92536f551de34b95158a0#body_text
is schema:about of	named entity 'Impact' named entity 'Streptococcus' named entity 'INFLUENCE' named entity 'RESPONSES' named entity 'VIRAL' named entity 'SECONDARY INFECTIONS' named entity 'infections' named entity 'Lung' named entity 'Infection' named entity 'vaccine' named entity 'Lung' named entity 'Influenza' named entity 'imprinting' covid:arg/daa31dc5918bfaa7bda92536f551de34b95158a0 named entity 'Streptococcus pneumoniae' named entity 'Murine' named entity 'Pneumococcal Vaccine' named entity 'VACCINE EFFECTIVENESS' named entity 'adaptive immune responses' named entity 'Infection' named entity 'influence' named entity 'vaccine' named entity 'responses' named entity 'adaptive immune responses' named entity 'Changes' named entity 'innate' named entity 'viral' named entity 'Influenza' named entity 'secondary' named entity 'Effectiveness' named entity 'Murine' named entity 'imprinting' named entity 'CHANGES' named entity 'CAUSED BY' named entity 'SIGNIFICANT' named entity 'Vaccine' named entity 'Pneumococcal' named entity 'VACCINE' named entity 'IMPRINTING' named entity 'ADAPTIVE IMMUNE RESPONSES' named entity 'INDIRECT' named entity 'DIRECT' named entity 'INFLUENZA' named entity 'IMPACT' named entity 'AGED' named entity 'HAVE' named entity 'PNEUMOCOCCAL VACCINE' named entity 'MURINE LUNG' named entity 'STREPTOCOCCUS PNEUMONIAE INFECTION' nodeID://b56420950 nodeID://b56467702 nodeID://b56470702 nodeID://b56471062 nodeID://b56472066 nodeID://b56472374 nodeID://b56482742 nodeID://b56504906 nodeID://b56564382 nodeID://b56614842 nodeID://b56664222 nodeID://b56687622 nodeID://b56695890 nodeID://b56743366 nodeID://b56830962 nodeID://b56842426 nodeID://b56853054 nodeID://b56861762 nodeID://b56887294 nodeID://b56895578 nodeID://b56946130 nodeID://b56997786 nodeID://b57023110 nodeID://b57087714 nodeID://b57093250 nodeID://b57196466 nodeID://b57209078

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