About: Prolonged Shedding of Human Coronavirus in Hematopoietic Cell Transplant Recipients: Risk Factors and Viral Genome Evolution

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About: Prolonged Shedding of Human Coronavirus in Hematopoietic Cell Transplant Recipients: Risk Factors and Viral Genome Evolution Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Prolonged Shedding of Human Coronavirus in Hematopoietic Cell Transplant Recipients: Risk Factors and Viral Genome Evolution
Creator	Boeckh, Michael Kuypers, Jane Leisenring, Wendy Xie, Hu Ogimi, Chikara Waghmare, Alpana Englund, Janet Stevens-Ayers, Terry Jerome, Keith Greninger, Alexander Shean, Ryan
source	Medline; PMC
abstract	BACKGROUND: Recent data suggest that human coronavirus (HCoV) pneumonia is associated with significant mortality in hematopoietic cell transplant (HCT) recipients. Investigation of risk factors for prolonged shedding and intrahost genome evolution may provide critical information for development of novel therapeutics. METHODS: We retrospectively reviewed HCT recipients with HCoV detected in nasal samples by polymerase chain reaction (PCR). HCoV strains were identified using strain-specific PCR. Shedding duration was defined as time between first positive and first negative sample. Logistic regression analyses were performed to evaluate factors for prolonged shedding (≥21 days). Metagenomic next-generation sequencing (mNGS) was conducted when ≥4 samples with cycle threshold values of <28 were available. RESULTS: Seventeen of 44 patients had prolonged shedding. Among 31 available samples, 35% were OC43, 32% were NL63, 19% were HKU1, and 13% were 229E; median shedding duration was similar between strains (P = .79). Bivariable logistic regression analyses suggested that high viral load, receipt of high-dose steroids, and myeloablative conditioning were associated with prolonged shedding. mNGS among 5 subjects showed single-nucleotide polymorphisms from OC43 and NL63 starting 1 month following onset of shedding. CONCLUSIONS: High viral load, high-dose steroids, and myeloablative conditioning were associated with prolonged shedding of HCoV in HCT recipients. Genome changes were consistent with the expected molecular clock of HCoV.
has issue date	2017-05-30(xsd:dateTime)
bibo:doi	10.1093/infdis/jix264
bibo:pmid	28838146
has license	bronze-oa
sha1sum (hex)	da9053f430ca250740d6edc3316d6a2aca6f997b
schema:url	https://doi.org/10.1093/infdis/jix264
resource representing a document's title	Prolonged Shedding of Human Coronavirus in Hematopoietic Cell Transplant Recipients: Risk Factors and Viral Genome Evolution
has PubMed Central identifier	PMC5853311
has PubMed identifier	28838146
schema:publication	The Journal of Infectious Diseases
resource representing a document's body	covid:da9053f430ca250740d6edc3316d6a2aca6f997b#body_text
is schema:about of	named entity 'RISK FACTORS' named entity 'GENOME EVOLUTION' named entity 'shedding' named entity 'Transplant' named entity 'HEMATOPOIETIC CELL' named entity 'RISK FACTORS' named entity 'RECENT' named entity 'CELL TRANSPLANT' named entity 'HEMATOPOIETIC CELL' named entity 'ASSOCIATED WITH' named entity 'CELL TRANSPLANT' named entity 'SUGGEST' named entity 'VIRAL GENOME' named entity 'TRANSPLANT RECIPIENTS' named entity 'PROLONGED' named entity 'INVESTIGATION' named entity 'SHEDDING' named entity 'HUMAN CORONAVIRUS' named entity 'MORTALITY' named entity 'BACKGROUND' named entity 'DATA' named entity 'INFORMATION' named entity 'NOVEL THERAPEUTICS' named entity 'OF RISK' named entity 'CRITICAL' named entity 'HUMAN CORONAVIRUS' named entity 'GENOME EVOLUTION' named entity 'PROLONGED' named entity 'PNEUMONIA' named entity 'SIGNIFICANT' named entity 'DEVELOPMENT' named entity 'PROVIDE' named entity 'SHEDDING' covid:arg/da9053f430ca250740d6edc3316d6a2aca6f997b named entity 'human' named entity 'Background' named entity 'hematopoietic cell' named entity 'critical information' named entity 'pneumonia' named entity 'Human Coronavirus' named entity 'Genome Evolution' named entity 'HKU1' named entity 'pediatric' named entity 'steroid' named entity 'genome' named entity 'regression analysis' named entity 'Allele frequencies' named entity 'Fred Hutchinson Cancer Research Center' named entity 'molecular clock' named entity 'risk factors' named entity 'viral genomes' named entity 'lower respiratory tract' named entity 'Windows' named entity 'sample size' named entity 'transplant recipients' named entity 'genome evolution' named entity 'risk factors' named entity 'metagenomic' named entity 'myeloablative' named entity 'SAS Institute' named entity 'NL63' named entity 'PCR' named entity 'conditioning regimen' named entity 'respiratory symptoms' named entity 'pediatric' named entity 'Severe acute respiratory syndrome' named entity 'epidemiological' named entity 'reverse-transcription' named entity 'evolution' named entity 'molecular diagnostics' named entity 'genomes'

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