About: Antiviral Effect of Lithium Chloride and Diammonium Glycyrrhizinate on Porcine Deltacoronavirus In Vitro

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About: Antiviral Effect of Lithium Chloride and Diammonium Glycyrrhizinate on Porcine Deltacoronavirus In Vitro Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral Effect of Lithium Chloride and Diammonium Glycyrrhizinate on Porcine Deltacoronavirus In Vitro
Creator	Su, Shuo Zhai, Xiaofeng Zhu, Mengyan He, Wei Wang, Shilei Pan, Zhongzhou
Source	Medline; PMC
abstract	Porcine deltacoronavirus (PDCoV) is an emerging global swine virus that has a propensity for interspecies transmission. It was identified in Hong Kong in 2012. Given that neither specific antiviral drugs nor vaccines are available for newly emerging porcine deltacoronavirus, searching for effective antiviral drugs is a high priority. In this study, lithium chloride (LiCl) and diammonium glycyrrhizinate (DG), which are host-acting antivirals (HAAs), were tested against PDCoV. We found that LiCl and DG inhibited PDCoV replication in LLC-PK1 cells in a dose-dependent manner. The antiviral effects of LiCl and DG occurred at the early stage of PDCoV replication, and DG also inhibited virus attachment to the cells. Moreover, both drugs inhibited PDCoV-induced apoptosis in LLC-PK1 cells. This study suggests LiCl and DG as new drugs for the treatment of PDCoV infection.
has issue date	2019-09-09(xsd:dateTime)
bibo:doi	10.3390/pathogens8030144
bibo:pmid	31505777
has license	cc-by
sha1sum (hex)	da841082920197ef43a5d5bdb05b38ed7cccf9fe
schema:url	https://doi.org/10.3390/pathogens8030144
resource representing a document's title	Antiviral Effect of Lithium Chloride and Diammonium Glycyrrhizinate on Porcine Deltacoronavirus In Vitro
has PubMed Central identifier	PMC6789623
has PubMed identifier	31505777
schema:publication	Pathogens
resource representing a document's body	covid:da841082920197ef43a5d5bdb05b38ed7cccf9fe#body_text
is schema:about of	named entity 'deltacoronavirus' named entity 'antiviral drugs' named entity 'lithium chloride' named entity 'Deltacoronavirus' covid:arg/da841082920197ef43a5d5bdb05b38ed7cccf9fe named entity 'effective' named entity 'replication' named entity 'inhibited' named entity 'LiCl' named entity 'Given' named entity 'manner' named entity 'Antiviral' named entity 'interspecies transmission' named entity 'apoptosis' named entity 'Hong Kong' named entity 'dose-dependent manner' named entity 'virus' named entity 'swine' named entity 'lithium chloride' named entity 'LiCl' named entity 'Diammonium' named entity 'Lithium Chloride' named entity 'virus' named entity 'titer' named entity 'LiCl' named entity 'cell surface' named entity 'hpi' named entity 'apoptotic cells' named entity 'Apoptosis' named entity 'virions' named entity 'LiCl' named entity 'vRNA' named entity 'LiCl' named entity 'cell morphology' named entity 'mRNA' named entity 'mRNA expression' named entity 'Flow cytometry' named entity 'protein' named entity 'viruses' named entity 'viral replication' named entity 'dose-dependent manner' named entity 'infection' named entity 'hpi' named entity 'fluorescence' named entity 'water solubility' named entity 'antiviral' named entity 'vRNA' named entity 'LiCl' named entity 'MOI' named entity 'TCID50' named entity 'LiCl' named entity 'LiCl' named entity 'infection' named entity 'infection' named entity 'qPCR' named entity 'drug treatment' named entity 'virus' named entity 'LiCl' named entity 'LiCl' named entity 'gene expression' named entity 'viruses' named entity 'LiCl' named entity 'cell culture' named entity 'hpi' named entity 'multiplicity of infection' named entity 'dose-dependent' named entity 'antiviral' named entity 'mRNA' named entity 'titer' named entity 'BD Medical' named entity 'qPCR' named entity 'TCID50' named entity 'MOI' named entity 'MOI' named entity 'Shanghai' named entity 'LiCl'

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