About: Cytokines and acute phase proteins associated with acute swine influenza infection in pigs

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cytokines and acute phase proteins associated with acute swine influenza infection in pigs
Creator	Atanasova, Kalina Barbé, Filip Reeth, Kristien
topic	covid:d9c2c2d109095422b4d4a85d46b181e65bcf4d54#this
Source	Elsevier; Medline; PMC
abstract	Abstract This study set out to investigate the cytokines and acute phase proteins (APPs) associated with the acute stages of experimentally-induced swine influenza virus (SIV) infection in 3-week-old, colostrum-deprived, caesarean-derived piglets. The piglets were inoculated intratracheally with 107.5 50% egg infective dose [EID50] Swine/Belgium/1/98 (H1N1) SIV and were euthanased at time-points between 0 and 120h post-inoculation (PI). Broncho-alveolar lavage fluid (BALF), lung homogenates and sera were examined for inflammatory mediators by bioassay or ELISA. Interferon (IFN)-α, interleukin (IL)-6, IL-1 and tumour necrosis factor (TNF)-α peaked in BALF 24–30h PI, when virus titres and the severity of clinical signs were maximal. Whereas IFN-γ and IL-12, but not IL-18, increased in tandem in BALF, serum cytokine concentrations were either undetectable or were up to 100-fold lower. The APP C-reactive protein (CRP) and haptoglobin peaked 24h later than the cytokines and reached higher levels in serum than in BALF. In contrast, lipopolysaccharide (LPS)-binding protein (LBP) only increased in BALF. Lung virus titres tightly correlated with BALF IFN-α, IL-6, IL-1, TNF-α, IFN-γ and IL-12, as well as with serum IL-6, IFN-α and IFN-γ. Signs of disease correlated with the same cytokines in BALF and serum, as well as with BALF LBP and serum CRP. The findings suggest that IFN-γ and IL-12 play a role in the pathogenesis of SIV and that APPs are induced by cytokines. This influenza infection model may have value in assessing the therapeutic potential of cytokine antagonists.
has issue date	2011-01-31(xsd:dateTime)
bibo:doi	10.1016/j.tvjl.2009.12.012
bibo:pmid	20097110
has license	els-covid
sha1sum (hex)	d9c2c2d109095422b4d4a85d46b181e65bcf4d54
schema:url	https://doi.org/10.1016/j.tvjl.2009.12.012
resource representing a document's title	Cytokines and acute phase proteins associated with acute swine influenza infection in pigs
has PubMed Central identifier	PMC7129392
has PubMed identifier	20097110
schema:publication	The Veterinary Journal
resource representing a document's body	covid:d9c2c2d109095422b4d4a85d46b181e65bcf4d54#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/d9c2c2d109095422b4d4a85d46b181e65bcf4d54
is schema:about of	named entity 'infective' named entity 'TNF' named entity 'acute' named entity 'This' named entity 'INFLUENZA INFECTION' named entity 'ACUTE' named entity 'ALVEOLAR LAVAGE FLUID' named entity 'POST' named entity 'IL-1' named entity 'POINTS' named entity '120' covid:arg/d9c2c2d109095422b4d4a85d46b181e65bcf4d54 named entity 'ASSOCIATED WITH' named entity 'INTERLEUKIN ' named entity 'LUNG' named entity 'SEVERITY' named entity 'INOCULATION' named entity 'STAGES' named entity 'CYTOKINES' named entity 'ACUTE PHASE PROTEINS' named entity 'DERIVED' named entity 'INDUCED' named entity 'SET' named entity 'SWINE INFLUENZA' named entity 'CYTOKINES' named entity 'BRONCHO-ALVEOLAR LAVAGE' named entity 'ASSOCIATED WITH' named entity 'WEEK' named entity 'OLD' named entity 'MAXIMAL' named entity 'EXAMINED FOR' named entity 'EGG' named entity 'BIOASSAY' named entity '7.5' named entity 'ELISA' named entity 'INFECTIVE DOSE' named entity 'ACUTE' named entity 'SWINE INFLUENZA VIRUS' named entity 'SERA' named entity '2F1' named entity 'TUMOUR NECROSIS FACTOR' named entity 'INTERFERON ' named entity 'INFLAMMATORY MEDIATORS' named entity '50%' named entity 'STUDY' named entity 'VIRUS' named entity 'SIV' named entity 'PEAKED' named entity 'TIME' named entity 'ACUTE PHASE PROTEINS' named entity 'INFECTION' named entity 'TO INVESTIGATE' named entity 'SWINE' named entity 'PIGS' named entity 'interleukin' named entity 'egg' named entity 'investigate' named entity 'set' named entity 'BALF' named entity 'TNF' named entity 'tumour necrosis factor' named entity 'interleukin (IL)-6' named entity 'inoculation' named entity 'bioassay' named entity 'swine influenza' named entity 'infection' named entity 'ng/mL' named entity 'IFN-a' named entity 'IL-6' named entity 'Van Reeth' named entity 'IL-8' named entity 'cytopathic effect' named entity 'correlation' named entity 'Neutrophil' named entity 'euthanased' named entity 'pathogenesis' named entity 'protein'

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