About: Memory in Retroviral Quasispecies: Experimental Evidence and Theoretical Model for Human Immunodeficiency Virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Memory in Retroviral Quasispecies: Experimental Evidence and Theoretical Model for Human Immunodeficiency Virus
Creator	Briones, Carlos Domingo, Esteban Molina-París, Carmen
source	Elsevier; Medline; PMC
abstract	Abstract Viral quasispecies may possess a molecular memory of their past evolutionary history, imprinted on minority components of the mutant spectrum. Here we report experimental evidence and a theoretical model for memory in retroviral quasispecies in vivo. Apart from replicative memory associated with quasispecies dynamics, retroviruses may harbour a “cellular” or “anatomical” memory derived from their integrative cycle and the presence of viral reservoirs in body compartments. Three independent sets of data exemplify the two kinds of memory in human immunodeficiency virus type 1 (HIV-1). The data provide evidence of re-emergence of sequences that were hidden in cellular or anatomical compartments for extended periods of infection, and recovery of a quasispecies from pre-existing genomes. We develop a three-component model that incorporates the essential features of the quasispecies dynamics of retroviruses exposed to selective pressures. Significantly, a numerical study based on this model is in agreement with the experimental data, further supporting the existence of both replicative and reservoir memory in retroviral quasispecies.
has issue date	2003-08-01(xsd:dateTime)
bibo:doi	10.1016/s0022-2836(03)00661-2
bibo:pmid	12875847
has license	els-covid
sha1sum (hex)	d8e9b9460d245145a00ceb2f8f6b1a49dbd2123e
schema:url	https://doi.org/10.1016/s0022-2836%2803%2900661-2
resource representing a document's title	Memory in Retroviral Quasispecies: Experimental Evidence and Theoretical Model for Human Immunodeficiency Virus
has PubMed Central identifier	PMC7173031
has PubMed identifier	12875847
schema:publication	Journal of Molecular Biology
resource representing a document's body	covid:d8e9b9460d245145a00ceb2f8f6b1a49dbd2123e#body_text
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