About: Zebrafish and Medaka: new model organisms for modern biomedical research

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Zebrafish and Medaka: new model organisms for modern biomedical research Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Zebrafish and Medaka: new model organisms for modern biomedical research
Creator	Lin, Cheng-Yung Tsai, Huai-Jen Chiang, Cheng-Yi
Source	PMC
abstract	Although they are primitive vertebrates, zebrafish (Danio rerio) and medaka (Oryzias latipes) have surpassed other animals as the most used model organisms based on their many advantages. Studies on gene expression patterns, regulatory cis-elements identification, and gene functions can be facilitated by using zebrafish embryos via a number of techniques, including transgenesis, in vivo transient assay, overexpression by injection of mRNAs, knockdown by injection of morpholino oligonucleotides, knockout and gene editing by CRISPR/Cas9 system and mutagenesis. In addition, transgenic lines of model fish harboring a tissue-specific reporter have become a powerful tool for the study of biological sciences, since it is possible to visualize the dynamic expression of a specific gene in the transparent embryos. In particular, some transgenic fish lines and mutants display defective phenotypes similar to those of human diseases. Therefore, a wide variety of fish model not only sheds light on the molecular mechanisms underlying disease pathogenesis in vivo but also provides a living platform for high-throughput screening of drug candidates. Interestingly, transgenic model fish lines can also be applied as biosensors to detect environmental pollutants, and even as pet fish to display beautiful fluorescent colors. Therefore, transgenic model fish possess a broad spectrum of applications in modern biomedical research, as exampled in the following review.
has issue date	2016-01-28(xsd:dateTime)
bibo:doi	10.1186/s12929-016-0236-5
bibo:pmid	26822757
has license	cc-by
sha1sum (hex)	d8e7b7463d9d1de0dbc5582aa94cf684ac9626fd
schema:url	https://doi.org/10.1186/s12929-016-0236-5
resource representing a document's title	Zebrafish and Medaka: new model organisms for modern biomedical research
has PubMed Central identifier	PMC4730764
has PubMed identifier	26822757
schema:publication	J Biomed Sci
resource representing a document's body	covid:d8e7b7463d9d1de0dbc5582aa94cf684ac9626fd#body_text
is schema:about of	named entity 'vertebrates' named entity 'zebrafish' named entity 'mutagenesis' named entity 'phenotypes' named entity 'detect' named entity 'disease' named entity 'colors' named entity 'KNOCKOUT' named entity 'HARBORING' named entity 'POSSESS' named entity 'TRANSIENT' named entity 'BIOLOGICAL SCIENCES' named entity 'USED' named entity 'TOOL' named entity 'TISSUE' named entity 'USING' named entity 'DRUG' named entity 'injection' named entity 'identification' named entity 'transgenesis' named entity 'transient' named entity 'pathogenesis' named entity 'fish' named entity 'gene' named entity 'drug' named entity 'model organisms' named entity 'biosensors' named entity 'Therefore' named entity 'applications' named entity 'fluorescent' named entity 'living' named entity 'model organisms' named entity 'molecular mechanisms' named entity 'Cas9' named entity 'cis' named entity 'zebrafish' named entity 'transgenic' named entity 'gene expression' named entity 'gene' named entity 'transgenic' named entity 'biosensors' named entity 'Medaka' named entity 'mutants' named entity 'fish' named entity 'gene' named entity 'miR-206' named entity 'Myf5' named entity 'psychopharmacological' named entity 'differentially expressed genes' named entity 'heart development' named entity 'haploid' named entity 'foxd3' named entity 'lymphoid cells' named entity 'evolution' named entity 'blood circulation' named entity 'electrocardiogram' named entity 'erythroid' named entity 'acute myeloid leukemia' named entity 'zebrafish' named entity 'phenotypes' named entity 'antipsychotics' named entity 'miR' named entity 'Myod' named entity 'vertebrates' named entity 'homologous protein' named entity 'Myod' named entity 'Hami' named entity 'neuron' named entity 'phenotypes' named entity 'tumor suppressor genes' named entity 'zebrafish' named entity 'developing embryos' named entity 'miRNAs' named entity 'germline' named entity 'mutagens' named entity 'mesoderm' named entity 'angiogenesis' named entity 'ectopic expression' named entity 'cell fates'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software