About: SARS-CoV-2 Seroprevalence Across a Diverse Cohort of Healthcare Workers

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS-CoV-2 Seroprevalence Across a Diverse Cohort of Healthcare Workers
Creator	Jain, Mohit Ba, Albert, Christine Cheng, Susan Ebinger, Joseph Figueiredo, Jane Grein, Jonathan Karin, Michael Sharma, Sonia Arditi, Moshe Berg, Anders Botting, Patrick Kim, Elizabeth Liu, Yunxian Luong, Eric Nguyen, Trevor-Trung Raedschelders, Koen Sun, Nancy Van Eyk, Jennifer Botwin, Gregory Braun, Jonathan Li, Dalin Mcgovern, Dermot Widjaja, F Merin, Noah Binek, Aleksandra Hasan, Wohaib Henglin, Mir Hussain, Shehnaz Joung, Sandy Miles, Peggy Minissian, Margo Rashid, Mohamad Riggs, Richard Sobhani, Kimia Tourtellotte, Warren Alotaibi, Mona Fert-Bober, Justyna Merchant, Akil Riera, Celine Sternbach, Sarah
Source	MedRxiv
abstract	Importance: Antibody testing is important for understanding patterns of exposure and potential immunity to SARS-CoV-2. Prior data on seroprevalence have been subject to variations in selection of individuals and nature as well as timing of testing in relation to exposures. Objective: We sought to determine the extent of SARS-CoV-2 seroprevalance and the factors associated with seroprevelance across a diverse cohort of healthcare workers. Design: Observational cohort study of healthcare workers, including SARS-CoV-2 serology testing and participant questionaires. Participants: A diverse and unselected population of adults (n=6,062) employed in a multi-site healthcare delivery system located in Los Angeles County, including individuals with direct patient contact and others with non-patient-oriented work functions. Exposure: Exposure and infection with the SARS-CoV-2 virus, as determined by seropositivity. Main Outcomes: Using Bayesian and multi-variate analyses, we estimated seroprevalence and factors associated with seropositivity and antibody titers, including pre-existing demographic and clinical characteristics; potential Covid-19 illness related exposures; and, symptoms consistent with Covid-19 infection. Results: We observed a seroprevalence rate of 4.1%, with anosmia as the most prominently associated self-reported symptom in addition to fever, dry cough, anorexia, and myalgias. After adjusting for potential confounders, pre-existing medical conditions were not associated with antibody positivity. However, seroprevalence was associated with younger age, Hispanic ethnicity, and African-American race, as well as presence of either a personal or household member having a prior diagnosis of Covid-19. Importantly, African American race and Hispanic ethnicity were associated with antibody positivity even after adjusting for personal Covid-19 diagnosis status, suggesting the contribution of unmeasured structural or societally factors. Notably, number of people, or children, in the home was not associated with antibody positivity. Conclusion and Relevance: The demographic factors associated with SARS-CoV-2 seroprevalence among our healthcare workers underscore the importance of exposure sources beyond the workplace. The size and diversity of our study population, combined with robust survey and modeling techniques, provide a vibrant picture of the demographic factors, exposures, and symptoms that can identify individuals with susceptibility as well as potential to mount an immune response to Covid-19.
has issue date	2020-08-04(xsd:dateTime)
bibo:doi	10.1101/2020.07.31.20163055
has license	medrxiv
sha1sum (hex)	d8ddfef3f0358553cdf1330282c734c0611f301c
schema:url	https://doi.org/10.1101/2020.07.31.20163055
resource representing a document's title	SARS-CoV-2 Seroprevalence Across a Diverse Cohort of Healthcare Workers
resource representing a document's body	covid:d8ddfef3f0358553cdf1330282c734c0611f301c#body_text
is schema:about of	named entity 'healthcare' named entity 'SARS-CoV-2' named entity 'seropositivity' named entity 'symptom' named entity 'Healthcare' named entity 'CLINICAL' named entity 'RATE' named entity 'SEROPOSITIVITY' named entity 'ANOSMIA' named entity 'observed' named entity 'seroprevalence' named entity 'anosmia' named entity 'seroprevalence' named entity 'healthcare worker' named entity 'SARS-CoV-2' named entity 'demographic factors' named entity 'seropositive' named entity 'test characteristics' named entity 'antibody' named entity 'seroprevalence' named entity 'antibody' named entity 'Covid' named entity 'PCR' named entity 'Cedars-Sinai' named entity 'T-cell' named entity 'healthcare workers' named entity 'symptom' named entity 'antibodies' named entity 'SARS-CoV-2 virus' named entity 'clinical characteristics' named entity 'antibodies' named entity 'antibody' named entity 'Covid' named entity 'Covid' named entity 'antibody' named entity 'antibody' named entity 'humoral immune response' named entity 'Iterative Proportional Fitting' named entity 'infection' named entity 'informed consent' named entity 'ethnicity' named entity 'antibody testing' named entity 'risk factors' named entity 'dyspnea' named entity 'study population'

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