About: Slicing and dicing viruses: antiviral RNA interference in mammals

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Slicing and dicing viruses: antiviral RNA interference in mammals
Creator	Maillard, Pierre Poirier, Enzo Reis E Sousa, Caetano Van Der Veen, Annemarthe
Source	Medline; PMC
abstract	To protect against the harmful consequences of viral infections, organisms are equipped with sophisticated antiviral mechanisms, including cell‐intrinsic means to restrict viral replication and propagation. Plant and invertebrate cells utilise mostly RNA interference (RNAi), an RNA‐based mechanism, for cell‐intrinsic immunity to viruses while vertebrates rely on the protein‐based interferon (IFN)‐driven innate immune system for the same purpose. The RNAi machinery is conserved in vertebrate cells, yet whether antiviral RNAi is still active in mammals and functionally relevant to mammalian antiviral defence is intensely debated. Here, we discuss cellular and viral factors that impact on antiviral RNAi and the contexts in which this system might be at play in mammalian resistance to viral infection.
has issue date	2019-03-15(xsd:dateTime)
bibo:doi	10.15252/embj.2018100941
bibo:pmid	30872283
has license	cc-by
sha1sum (hex)	d897dfae4f3b4d98b4bb6fde108a29c253d87e50
schema:url	https://doi.org/10.15252/embj.2018100941
resource representing a document's title	Slicing and dicing viruses: antiviral RNA interference in mammals
has PubMed Central identifier	PMC6463209
has PubMed identifier	30872283
schema:publication	EMBO J
resource representing a document's body	covid:d897dfae4f3b4d98b4bb6fde108a29c253d87e50#body_text
is schema:about of	named entity 'resistance' named entity 'immunity' named entity 'RNAi' named entity 'MEANS' named entity 'MECHANISM' named entity 'VERTEBRATE' named entity 'DROSOPHILA' named entity 'CONSERVED' named entity 'DISCUSS' named entity 'SYSTEM' named entity 'ACTIVE' named entity 'RESISTANCE TO' named entity 'INCLUDING' named entity 'INNATE IMMUNE SYSTEM' named entity 'CONTEXTS' named entity 'VIROL' named entity 'MAMMALS' named entity 'MG%' named entity 'DIRECTED' named entity 'INTRINSIC' named entity 'HERE' named entity 'ORGANISMS' named entity 'MACHINERY' named entity 'IMMUNITY' named entity 'PURPOSE' named entity 'PLAY' named entity 'MAMMALIAN' named entity 'RELEVANT' named entity 'RNAI' named entity 'VIRAL REPLICATION' named entity 'CONSEQUENCES' named entity 'BASED' named entity 'SUPPRESSION' named entity 'ASSOCIATED' named entity 'INTERFERON ' named entity 'IMPACT' named entity 'CELLULAR' named entity 'MECHANISMS' named entity 'VIRAL INFECTION' named entity 'DRIVEN' named entity 'VIRAL INFECTIONS' named entity 'PROPAGATION' named entity 'INVERTEBRATE' named entity 'ANTIVIRAL' named entity 'MAMMALS' named entity 'RNA' named entity 'MICROBE' named entity 'HOST' named entity 'MIGHT BE' named entity 'DERIVED' named entity 'RESTRICT' named entity 'VIRUSES' named entity 'INDUCTION' named entity 'CELLS' named entity 'RNA INTERFERENCE' named entity 'VERTEBRATES' named entity 'SMALL' named entity 'ADENOVIRUS' named entity 'VIRUSES' named entity 'CELL' named entity 'PROTEIN' named entity 'RNA INTERFERENCE' named entity 'VIRUS' named entity 'HARMFUL' named entity 'PLANT' named entity 'VIRAL' named entity 'BERKHOUT' named entity 'ANTIVIRAL' named entity 'interferon' named entity 'vertebrate' named entity 'cellular' named entity 'innate immune system' named entity 'mammals' named entity 'Microbe' named entity 'RNA interference' named entity 'antiviral' named entity 'RNA' named entity 'viral infection'

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