About: Interferon alfacon1 is an inhibitor of SARS-corona virus in cell-based models

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Interferon alfacon1 is an inhibitor of SARS-corona virus in cell-based models Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Interferon alfacon1 is an inhibitor of SARS-corona virus in cell-based models
Creator	Paragas, Jason Hartmann, Chris Huggins, John Blatt, Lawrence Endy, Tim
source	Elsevier; Medline; PMC
abstract	Abstract Preliminary data examining interferon alfacon1 treatment of SARS-CoV (severe acute respiratory syndrome-corona virus)-infected patients suggests this therapy is well tolerated and of therapeutic benefit. We report herein that interferon alfacon1, has potent in vitro antiviral activity against SARS-CoV. In a cytopathic effect protection (CPE) assay, interferon alfacon1 inhibited the generation of CPE in a dose-dependent manner with an IC50 of 0.001μg/ml, a clinically achievable level. Furthermore, interferon alfacon1 also demonstrated significant antiviral activity in yield reduction and plaque reduction assays. The in vitro antiviral activity of interferon alfacon1 against SARS-CoV suggests continued evaluation of interferon alfacon1 as a therapeutic treatment for patients infected with SARS-CoV.
has issue date	2005-06-30(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2005.01.002
bibo:pmid	15911026
has license	els-covid
sha1sum (hex)	d88886c3bc8373df053468a58836190b5fc043ca
schema:url	https://doi.org/10.1016/j.antiviral.2005.01.002
resource representing a document's title	Interferon alfacon1 is an inhibitor of SARS-corona virus in cell-based models
has PubMed Central identifier	PMC7114208
has PubMed identifier	15911026
schema:publication	Antiviral Research
resource representing a document's body	covid:d88886c3bc8373df053468a58836190b5fc043ca#body_text
is schema:about of	named entity 'Preliminary' named entity 'Elsevier B.V.' named entity 'severe' named entity 'CORONA' named entity 'CELL' named entity 'REDUCTION' named entity 'CORONA' named entity 'CYTOPATHIC EFFECT' named entity 'PRELIMINARY DATA' named entity 'INTERFERON ' named entity 'PUBLISHED' named entity 'DEMONSTRATED' named entity 'SYNDROME' covid:arg/d88886c3bc8373df053468a58836190b5fc043ca named entity 'DOSE-DEPENDENT' named entity 'THERAPEUTIC' named entity 'ASSAY' named entity 'TREATMENT' named entity 'INHIBITED' named entity 'EVALUATION' named entity 'PLAQUE' named entity 'ACUTE' named entity 'EXAMINING' named entity 'ANTIVIRAL ACTIVITY' named entity 'THERAPY' named entity 'IN VITRO' named entity 'PATIENTS' named entity 'PROTECTION' named entity 'CPE' named entity 'INHIBITOR' named entity 'SARS-COV' named entity 'INTERFERON ' named entity 'MODELS' named entity 'BASED' named entity 'SARS' named entity 'VIRUS' named entity 'BENEFIT' named entity 'CONTINUED' named entity 'REPORT' named entity '0.001' named entity 'LEVEL' named entity 'RESPIRATORY' named entity 'SIGNIFICANT' named entity 'INFECTED' named entity 'GENERATION' named entity 'VIRUS' named entity 'YIELD' named entity 'infected' named entity 'activity' named entity 'SARS-CoV' named entity 'patients' named entity 'antiviral activity' named entity 'severe acute respiratory syndrome' named entity 'SARS-CoV' named entity 'interferon' named entity 'interferon' named entity 'SARS-CoV' named entity 'interferon' named entity 'SARS-CoV' named entity 'interferon' named entity 'interferon' named entity 'SARS' named entity 'refractory' named entity 'type 1 interferon' named entity 'steroids' named entity 'hepatitis C virus' named entity 'dye' named entity 'treating SARS' named entity 'SARS-CoV' named entity 'interferon' named entity 'global health' named entity 'neutral red' named entity 'interferon' named entity 'interferon' named entity 'therapeutic agent' named entity 'Interferon' named entity 'coronavirus'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software