About: Covid-19 serology in nephrology health care workers

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Covid-19 serology in nephrology health care workers
Creator	Holzer, Barbara Mayer, Katharina Aigner, Christof Atamaniuk, Johanna Födinger, Manuela Gaggl, Martina Gerges, Daniela Jansen-Skoupy, Sonja Pajenda, Sahra Reiter, Thomas Schmidt, Alice Straßl, Robert Sunder-Plassmann, Gere Wagner, Ludwig Zimpernik, Irene
Source	MedRxiv
abstract	Background: Chronic kidney disease patients show a high mortality in case of a SARS-CoV-2 infection. Thus, to be informed on Nephrology personnel's sero-status might be crucial for patient protection. However, limited information exists about the presence of SARS-CoV-2 antibodies in asymptomatic individuals. Methods: We examined the seroprevalence of SARS-CoV-2 IgG and IgM antibodies among health care workers of a tertiary care kidney center during the peak phase of the Covid-19 crisis in Austria using an orthogonal test strategy and a total of 12 commercial nucleocapsid protein or spike glycoprotein based assays as well as Western blotting and a neutralization assay. Results: At baseline 60 of 235 study participants (25.5%, 95% CI: 20.4-31.5) were judged to be borderline positive or positive for IgM or IgG using a high sensitivity/low specificity threshold in one test system. Follow-up analysis after about two weeks revealed IgG positivity in 12 (5.1%, 95% CI: 2.9-8.8) and IgM positivity in six (2.6%, 95% CI: 1.1-5.6) in at least one assay. 2.1% (95% CI: 0.8-5.0) of health care workers showed IgG nucleocapsid antibodies in at least two assays. By contrast, positive controls with proven Covid-19 showed antibody positivity among almost all test systems. Moreover, serum samples obtained from health care workers did not show SARS-CoV-2 neutralizing capacity, in contrast to positive controls. Conclusions: Using a broad spectrum of antibody tests the present study revealed inconsistent results for SARS-CoV-2 seroprevalence among asymptomatic individuals, while this was not the case among Covid-19 patients.
has issue date	2020-07-26(xsd:dateTime)
bibo:doi	10.1101/2020.07.21.20136218
has license	medrxiv
sha1sum (hex)	d8749662e6fe722629dc18442e52f7cc40c33938
schema:url	https://doi.org/10.1101/2020.07.21.20136218
resource representing a document's title	Covid-19 serology in nephrology health care workers
resource representing a document's body	covid:d8749662e6fe722629dc18442e52f7cc40c33938#body_text
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