About: Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses

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About: Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses
Creator	Hage, Adam Rajsbaum, Ricardo Shi, Pei-Yong Bukreyev, Alexander Xie, Xuping Shan, Chao Menachery, Vineet Bradrick, Shelton Garcia-Blanco, Mariano Mcanarney, Eileen Bedford, Mark Fagg, W Hirano, Minato Pietzsch, Colette Prasanth, K
Source	BioRxiv; Medline; PMC
abstract	Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-ß (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded RNA viruses tested, including SARS-CoV-2. While there are no drugs that specifically inhibit this topoisomerase, we posit that TOP3B is an attractive anti-viral target.
has issue date	2020-03-27(xsd:dateTime)
bibo:doi	10.1101/2020.03.24.005900
bibo:pmid	32511318
has license	cc-by-nc-nd
sha1sum (hex)	d84a3e0fca704a75836e97efd3b413fda649a54f
schema:url	https://doi.org/10.1101/2020.03.24.005900
resource representing a document's title	Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses
has PubMed Central identifier	PMC7239047
has PubMed identifier	32511318
schema:publication	bioRxiv
resource representing a document's body	covid:d84a3e0fca704a75836e97efd3b413fda649a54f#body_text
is schema:about of	named entity 'yellow fever virus' named entity 'POSITIVE' named entity 'REPLICATION' named entity 'RNA' named entity 'acts' named entity 'dengue virus' named entity 'DNA' named entity 'positive-sense' named entity 'TOP3B' named entity 'DNA and RNA' named entity 'methylated' named entity 'plasmids' named entity 'viral genome' named entity 'DENV' named entity 'gene' named entity 'genomes' named entity 'RNA viruses' named entity 'drug targets' named entity 'mutation' named entity 'viruses' named entity 'SARS-CoV-2' named entity 'TOP3B' named entity 'HuH-7' named entity 'DNA and RNA' named entity 'YFV' named entity 'viral replication' named entity 'loss-of-function' named entity 'receptor' named entity 'virus replication' named entity 'pFLAG' named entity 'RNAi' named entity 'TOP3B' named entity 'RNA immunoprecipitation' named entity 'topoisomerase' named entity 'inflammation' named entity 'chikungunya virus' named entity 'proviral' named entity 'HuH-7' named entity 'TOP3B' named entity 'TOP3B' named entity 'topoisomerase' named entity 'homozygous' named entity 'Zika' named entity 'GFP' named entity 'RNA' named entity 'CST' named entity 'Coronaviridae' named entity 'protein' named entity 'normal distribution' named entity '293T' named entity 'RNA viruses' named entity 'Santa Cruz Biotechnology' named entity 'monoclonal antibodies' named entity 'ACE-2' named entity 'Actin' named entity 'SARS-CoV-2' named entity 'RNA virus' named entity 'TOP3B' named entity 'virions' named entity 'DENV' named entity 'SARS-CoV' named entity 'ZIKV' named entity 'viral replication' named entity 'coxsackievirus B3' named entity 'catenanes' named entity 'titer' named entity 'ZIKV'

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